Enantioselective borohydride reduction of ketones catalyzed by optically active cobalt(II) complexes: Achievement of high enantioselection by modified borohydrides with furfuryl alcohol derivatives

被引：38

作者：

Sugi, KD ^{[1
]}

Nagata, T ^{[1
]}

Yamada, T ^{[1
]}

Mukaiyama, T ^{[1
]}

机构：

[1] SCI UNIV TOKYO, FAC SCI, DEPT APPL CHEM, SHINJUKU KU, TOKYO 162, JAPAN

来源：

CHEMISTRY LETTERS | 1996年 / 09期

关键词：

D O I：

10.1246/cl.1996.737

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective borohydride reduction of ketones catalyzed by optically active (beta-oxoaldiminato) cobalt(II) complexes was remarkably improved by using the borohydride which was modified with furfuryl alcohol derivatives and ethanol. In the presence of 1 mol% of the above complex catalysts, asymmetric reduction of aromatic ketones proceeded smoothly to give the corresponding optically active alcohols in quantitative yields within 6-12 h with high enantiomeric excesses (90-97% ee).

引用

页码：737 / 738

页数：2

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