Asymmetric synthesis of diarylmethylamines: preparation of selective opioid delta receptor ligands

被引：40

作者：

Delorme, D ^{[1
]}

Berthelette, C ^{[1
]}

Lavoie, R ^{[1
]}

Roberts, E ^{[1
]}

机构：

[1] Astra Res Ctr Montreal, Dept Med Chem, St Laurent, PQ H4S 1Z9, Canada

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 22期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0957-4166(98)00419-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two different methods were used for the construction of optically active diarylmethylamines. Diastereoselective alkylation on an aldimine/oxazolidine 2a/2b derived from (R)/(S)phenylglycinol or enantioselective reduction of 4-[eta(6)-chromium tricarbonylbenzoyl] bromobenzene using chiral oxazoborolidine followed by amine introduction to furnish optically active diarylmethylamines. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3963 / 3966

页数：4

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