Towards a fully synthetic carbohydrate-based anticancer vaccine: Synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated Tn antigen

被引：123

作者：

Buskas, T ^{[1
]}

Ingale, S ^{[1
]}

Boons, GJ ^{[1
]}

机构：

[1] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 37期

关键词：

antitumor agents; glycopeptides; liposomes; solid-phase synthesis;

D O I：

10.1002/anie.200501818

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A spoonful of sugar ... A carbohydrate-based fully synthetic vaccine 1, composed of a tumor-associated Tn antigen, a peptide Tepitope, and a lipopeptide (see structure), shows potential as a candidate against cancer. Incorporation of the glycolipopeptide into liposomes gave a formulation that was able to elicit a T cell dependent antibody response in mice. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5985 / 5988

页数：4

共 40 条

[1] Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 [J].

Aliprantis, AO ;

Yang, RB ;

Mark, MR ;

Suggett, S ;

Devaux, B ;

Radolf, JD ;

Klimpel, GR ;

Godowski, P ;

Zychlinsky, A .

SCIENCE, 1999, 285 (5428) :736-739

[2]

ANDERSON PW, 1989, J IMMUNOL, V142, P2464

[3]

[Anonymous], ANGEW CHEM

[4] COVALENT LIPOPROTEIN FROM OUTER MEMBRANE OF ESCHERICHIA-COLI [J].

BRAUN, V .

BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 415 (03) :335-377

[5] The immunogenicity of the tumor-associated antigen Lewisy may be suppressed by a bifunctional cross-linker required for coupling to a carrier protein [J].

Buskas, T ;

Li, YH ;

Boons, GJ .

CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (14) :3517-3524

[6] 1-HYDROXY-7-AZABENZOTRIAZOLE - AN EFFICIENT PEPTIDE COUPLING ADDITIVE [J].

CARPINO, LA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (10) :4397-4398

[7]

Danishefsky S. J., 2000, ANGEW CHEM, V112, P882

[8]

Danishefsky SJ, 2000, ANGEW CHEM INT EDIT, V39, P836, DOI 10.1002/(SICI)1521-3773(20000303)39:5<836::AID-ANIE836>3.0.CO

[9]

2-I

[10] CARBOHYDRATE STRUCTURES OF GLYCOPROTEINS AND GLYCOLIPIDS AS DIFFERENTIATION ANTIGENS, TUMOR-ASSOCIATED ANTIGENS AND COMPONENTS OF RECEPTOR SYSTEMS [J].

FEIZI, T ;

CHILDS, RA .

TRENDS IN BIOCHEMICAL SCIENCES, 1985, 10 (01) :24-29

← 1 2 3 4 →