Towards a fully synthetic carbohydrate-based anticancer vaccine: Synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated Tn antigen

被引：123

作者：

Buskas, T ^{[1
]}

Ingale, S ^{[1
]}

Boons, GJ ^{[1
]}

机构：

[1] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 37期

关键词：

antitumor agents; glycopeptides; liposomes; solid-phase synthesis;

D O I：

10.1002/anie.200501818

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A spoonful of sugar ... A carbohydrate-based fully synthetic vaccine 1, composed of a tumor-associated Tn antigen, a peptide Tepitope, and a lipopeptide (see structure), shows potential as a candidate against cancer. Incorporation of the glycolipopeptide into liposomes gave a formulation that was able to elicit a T cell dependent antibody response in mice. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5985 / 5988

页数：4

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