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Induction and effector functions of TH17 cells

被引：978
作者：
Bettelli, Estelle [1 ]
Korn, Thomas [1 ]
Oukka, Mohamed [1 ]
Kuchroo, Vijay K. [1 ]
机构：
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
来源：
NATURE | 2008年 / 453卷 / 7198期
关键词：
D O I：
10.1038/nature07036
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
T helper (T-H) cells constitute an important arm of the adaptive immune system because they coordinate defence against specific pathogens, and their unique cytokines and effector functions mediate different types of tissue inflammation. The recently discovered T(H)17 cells, the third subset of effector T helper cells, have been the subject of intense research aimed at understanding their role in immunity and disease. Here we review emerging data suggesting that T(H)17 cells have an important role in host defence against specific pathogens and are potent inducers of autoimmunity and tissue inflammation. In addition, the differentiation factors responsible for their generation have revealed an interesting reciprocal relationship with regulatory T (T-reg) cells, which prevent tissue inflammation and mediate self-tolerance.
引用
收藏
页码：1051 / 1057
页数：7
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