Oxidative damage to extracellular matrix and its role in human pathologies

被引:173
作者
Rees, Martin D. [1 ]
Kennett, Eleanor C. [1 ]
Whitelock, John M. [2 ]
Davies, Michael J. [1 ,3 ]
机构
[1] Heart Res Inst, Camperdown, NSW 2050, Australia
[2] Univ New S Wales, Grad Sch Biomed Engn, Kensington, NSW 2052, Australia
[3] Univ Sydney, Fac Med, Sydney, NSW 2006, Australia
基金
澳大利亚研究理事会; 英国医学研究理事会;
关键词
extracellular matrix; glycosaminoglycan; proteoglycan; protein oxidation; oxidative stress; radicals; metal ions; peroxynitrite; myeloperoxidase;
D O I
10.1016/j.freeradbiomed.2008.03.016
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The extracellular compartments of most biological tissues are significantly less well protected against oxidative damage than intracellular sites and there is considerable evidence for such compartments being subject to a greater oxidative stress and an altered redox balance. However, with some notable exceptions (e.g., plasma and lung lining fluid) oxidative damage within these compartments has been relatively neglected and is poorly understood. In particular information on the nature and consequences of damage to extracellular matrix is lacking despite the growing realization that changes in matrix structure can play a key role in the regulation of cellular adhesion, proliferation, migration, and cell signaling. Furthermore, the extracellular matrix is widely recognized as being a key site of cytokine and growth factor binding, and modification of matrix structure might be expected to alter such behavior. In this paper we review the potential sources of oxidative matrix damage, the changes that occur in matrix structure, and how this may affect cellular behavior. The role of such damage in the development and progression of inflammatory diseases is discussed. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:1973 / 2001
页数:29
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