Challenges in the use of carbon nanotubes for biomedical applications

被引：51

作者：

Mehra, Neelesh Kumar ^{[1
]}

Jain, Amit Kumar ^{[1
]}

Lodhi, Neeraj ^{[1
]}

Raj, Rakesh ^{[1
]}

Dubey, Vaibhav ^{[1
]}

Mishra, Dinesh ^{[1
]}

Nahar, Manoj ^{[1
]}

Jain, N. K. ^{[1
]}

机构：

[1] Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Pharmaceut Res Lab, Sagar 470003, India

来源：

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS | 2008年 / 25卷 / 02期

关键词：

carbon nanotubes; purification; functionalization; biocompatibility; delivery;

D O I：

10.1615/CritRevTherDrugCarrierSyst.v25.i2.20

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Carbon nanotubes (CNTs) are considered for use in numerous technological applications, including as biocompatible modules for the delivery of bioactives. However, there are unique properties of CNTs that limit their use as vehicles for various purposes. This review highlights the various challenges to a pharmaceutical scientist while exploring CNTs as bioactive delivery vehicles. The lack of solubility, nonbiodegradability, circulation half-life of 3-3.5 hours, biocompatibility, and immunogenicity limitations of CNTs are discussed in this review. These limitations indicate the need for modifications in order to explore the feasibility of CNTs as delivery vehicles.

引用

页码：169 / 206

页数：38

共 150 条

[1] Investigations on the toxicological profile of functionalized fifth-generation poly(propylene imine) dendrimer [J].

Agashe, Hrushikesh B. ;

Dutta, Tathagata ;

Garg, Minakshi ;

Jain, N. K. .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2006, 58 (11) :1491-1498

[2] Carbon nanohorns as anticancer drug carriers [J].

Ajima, Kumiko ;

Yudasaka, Masako ;

Murakami, Tatsuya ;

Maigne, Alan ;

Shiba, Kiyotaka ;

Ijima, Sumio .

MOLECULAR PHARMACEUTICS, 2005, 2 (06) :475-480

[3] Solid lipid nanodispersions containing mixed lipid core and a polar heterolipid:: Characterization [J].

Attama, A. A. ;

Schicke, B. C. ;

Paepenmueller, T. ;

Mueller-Goymann, C. C. .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2007, 67 (01) :48-57

[4] Dendrimers: a new class of nanoscopic containers and delivery devices [J].

Aulenta, F ;

Hayes, W ;

Rannard, S .

EUROPEAN POLYMER JOURNAL, 2003, 39 (09) :1741-1771

[5] Chemically functionalized carbon nanotubes [J].

Balasubramanian, K ;

Burghard, M .

SMALL, 2005, 1 (02) :180-192

[6]

Balavoine F, 1999, ANGEW CHEM INT EDIT, V38, P1912, DOI 10.1002/(SICI)1521-3773(19990712)38:13/14<1912::AID-ANIE1912>3.0.CO

[7]

2-2

[8] Purification of single-wall carbon nanotubes by microfiltration [J].

Bandow, S ;

Rao, AM ;

Williams, KA ;

Thess, A ;

Smalley, RE ;

Eklund, PC .

JOURNAL OF PHYSICAL CHEMISTRY B, 1997, 101 (44) :8839-8842

[9] Covalent surface chemistry of single-walled carbon nanotubes [J].

Banerjee, S ;

Hemraj-Benny, T ;

Wong, SS .

ADVANCED MATERIALS, 2005, 17 (01) :17-29

[10] NEGATIVE STAINING OF PHOSPHOLIPIDS + THEIR STRUCTURAL MODIFICATION BY-SURFACE ACTIVE AGENTS AS OBSERVED IN ELECTRON MICROSCOPE [J].

BANGHAM, AD ;

HORNE, RW .

JOURNAL OF MOLECULAR BIOLOGY, 1964, 8 (05) :660-&

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