Regulating neutrophil apoptosis: new players enter the game

被引：103

作者：

Witko-Sarsat, Veronique ^{[1
,2
]}

Pederzoli-Ribeil, Magali ^{[1
,2
]}

Hirsh, Emilio ^{[3
]}

Sozzani, Silvano ^{[4
]}

Cassatella, Marco A. ^{[5
]}

机构：

[1] INSERM, U1016, F-75014 Paris, France

[2] Univ Paris 05, Inst Cochin, F-75014 Paris, France

[3] Univ Turin, Dept Genet Biol & Biochem, Ctr Mol Biotechnol, I-10124 Turin, Italy

[4] Univ Brescia, Dept Biomed Sci & Biotechnol, Brescia, Italy

[5] Univ Verona, Dept Pathol & Diagnost, Sect Gen Pathol, I-37134 Verona, Italy

来源：

TRENDS IN IMMUNOLOGY | 2011年 / 32卷 / 03期

关键词：

CELL-DEATH; IN-VIVO; POLYMORPHONUCLEAR NEUTROPHILS; GENE-EXPRESSION; DOWN-REGULATION; DRUG DISCOVERY; BONE-MARROW; NK CELLS; INFLAMMATION; ACTIVATION;

D O I：

10.1016/j.it.2011.01.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, unexpected biological features of polymorphonuclear neutrophils have been revealed. In addition to their pivotal role in the defence against pathogens, neutrophils display a high degree of plasticity and contribute to control of adaptive immune responses. An emerging aspect of neutrophils is their ability to modulate their survival in response to both intrinsic and extrinsic factors. This review focuses on recent advances that have uncovered proliferating cell nuclear antigen (PCNA) and other cell cycle regulatory proteins as novel players regulating neutrophil survival. A better understanding of the mechanisms involved in neutrophil fate might pave the way for the identification of new anti-inflammatory molecules.

引用

页码：117 / 124

页数：8

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