DNA polymerases in immunity: profiting from errors

被引：16

作者：

Storb, U ^{[1
]}

机构：

[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 06期

关键词：

D O I：

10.1038/88673

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple error-prone DNA polymerase appear to contribute to immunoglobulin somatic hypermutation. Genetic and biochemical data now indicate that DNA polymerase eta may be responsible for the generation of some of the strand-biased hotspot A mutations in the immunoglobulin loci.

引用

页码：484 / 485

页数：2

共 18 条

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