Clinical characteristics of linezolid-resistant Staphylococcus aureus infections

被引：52

作者：

Peeters, MJ

Sarria, JC

机构：

[1] Univ Texas, Med Branch, Dept Internal Med, Div Infect Dis, Galveston, TX 77555 USA

[2] Texas Tech Univ, Hlth Sci Ctr, Sch Pharm, Lubbock, TX 79430 USA

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 2005年 / 330卷 / 02期

关键词：

D O I：

10.1097/00000441-200508000-00007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Case reports have previously identified linezolid resistance in 6 clinical isolates of Staphylococcus aureus. We describe an additional case and discuss clinical characteristics of these patients. Invasive procedures, deep organ involvement, and presence of foreign material were predominant in these cases. Resistance followed prolonged (>21 days) linezolid therapy in most cases. The development of resistance to linezolid should be taken into account when selecting this drug as a therapeutic option.

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页码：102 / 104

页数：3

相关论文

共 11 条

[1] Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene [J].

Chang, S ;

Sievert, DM ;

Hageman, JC ;

Boulton, ML ;

Tenover, FC ;

Downes, FP ;

Shah, S ;

Rudrik, JT ;

Pupp, GR ;

Brown, WJ ;

Cardo, D ;

Fridkin, SK .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (14) :1342-1347

[2] Nosocomial spread of linezolid-resistant, vancomycin-resistant enterococcus faecium [J].

Herrero, IA ;

Issa, NC ;

Patel, R .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (11) :867-869

[3] TRIMETHOPRIM-SULFAMETHOXAZOLE COMPARED WITH VANCOMYCIN FOR THE TREATMENT OF STAPHYLOCOCCUS-AUREUS INFECTION [J].

MARKOWITZ, N ;

QUINN, EL ;

SARAVOLATZ, LD .

ANNALS OF INTERNAL MEDICINE, 1992, 117 (05) :390-398

[4] Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA [J].

Meka, VG ;

Pillai, SK ;

Sakoulas, G ;

Wennersten, C ;

Venkataraman, L ;

DeGirolami, PC ;

Eliopoulos, GM ;

Moellering, RC ;

Gold, HS .

JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (02) :311-317

[5] Reversion to susceptibility in a linezolid-resistant clinical isolate of Staphylococcus aureus [J].

Meka, VG ;

Gold, HS ;

Cooke, A ;

Venkataraman, L ;

Eliopoulos, GM ;

Moellering, RC ;

Jenkins, SG .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 54 (04) :818-820

[6] Antimicrobial resistance to linezolid [J].

Meka, VG ;

Gold, HS .

CLINICAL INFECTIOUS DISEASES, 2004, 39 (07) :1010-1015

[7] Linezolid resistance since 2001: SENTRY Antimicrobial Surveillance Program [J].

Mutnick, AH ;

Enne, V ;

Jones, RN .

ANNALS OF PHARMACOTHERAPY, 2003, 37 (06) :769-774

[8]

Paterson DL, 2003, ANN INTERN MED, V139, P863, DOI 10.7326/0003-4819-139-10-200311180-00017

[9] Linezolid resistance in a clinical isolate of Staphylococcus aureus [J].

Tsiodras, S ;

Gold, HS ;

Sakoulas, G ;

Eliopoulos, GM ;

Wennersten, C ;

Venkataraman, L ;

Moellering, RC ;

Ferraro, MJ .

LANCET, 2001, 358 (9277) :207-208

[10] Linezolid resistance in clinical isolates of Staphylococcus aureus [J].

Wilson, P ;

Andrews, JA ;

Charlesworth, R ;

Walesby, R ;

Singer, M ;

Farrell, DJ ;

Robbins, M .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (01) :186-187