Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression

被引：232

作者：

Kietzmann, T

Görlach, A

机构：

[1] Tech Univ Munich, Dept Pediat Cardiol & Congenital Heart Dis, German Heart Ctr, D-80636 Munich, Germany

[2] Univ Kaiserslautern, Fac Chem, Dept Biochem, D-67663 Kaiserslautern, Germany

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 4-5期

关键词：

hypoxia; reactive oxygen species; HIF; oxygen sensing; NADPH oxidase;

D O I：

10.1016/j.semcdb.2005.03.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactive oxygen species (ROS) have long been considered as cytotoxic. However, recent evidence indicates a prominent role of ROS as signaling molecules in the response to hormones, growth and coagulation factors, cytokines and other factors as well as to changes in oxygen tension. The hypoxia-inducible transcription factors (HIFs) are key players in the cellular response to changes in oxygen tension. Recently, HIFs have also been shown to respond to the above-mentioned non-hypoxic stimuli. In this article, the role of ROS in the regulation of HIF-1 under hypoxic and non-hypoxic conditions is summarized. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：474 / 486

页数：13

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