Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils

被引：63

作者：

Min, Dongyu ^{[1
]}

Mao, Xiaoyuan ^{[1
]}

Wu, Kuncan ^{[1
]}

Cao, Yonggang ^{[1
]}

Guo, Feng ^{[1
]}

Zhu, Shu ^{[2
]}

Xie, Ni ^{[1
]}

Wang, Lei

Chen, Tianbao

Shaw, Chris

Cai, Jiqun ^{[1
]}

机构：

[1] China Med Univ, Sch Pharmaceut Sci, Dept Pharmaceut Toxicol, Shenyang 110001, Peoples R China

[2] China Med Univ, Sch Stomatol, Dept Pediat Dent, Shenyang 110002, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2012年 / 510卷 / 01期

关键词：

Donepezil; Global cerebral ischemia; Neuroprotection; Memory; CAMK II; CREB; ELEMENT-BINDING PROTEIN; LONG-TERM POTENTIATION; KINASE-II; VASCULAR DEMENTIA; RAT-BRAIN; MEMORY; ACETYLCHOLINE; MICE; INJURY; PHOSPHORYLATION;

D O I：

10.1016/j.neulet.2011.12.064

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Decreased cerebral blood flow causes cognitive impairments and neuronal injury in vascular dementia. In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils. Treatment with 5 mg/kg of donepezil for 21 consecutive days following a 10-min period of ischemia significantly inhibited delayed neuronal death in the hippocampal CA1 region. In Morris water maze test, memory impairment was significantly improved by donepezil treatment. Western blot analysis showed that donepezil treatment prevented reductions in p-CaMKII and p-CREB protein levels in the hippocampus. These results suggest that donepezil attenuates the memory deficit induced by transient global cerebral ischemia and this neuroprotection may be associated with the phosphorylation of CaMKII and CERB in the hippocampus. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：29 / 33

页数：5

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