Transcription and processing of human microRNA precursors

被引：636

作者：

Cullen, BR ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

来源：

MOLECULAR CELL | 2004年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.molcel.2004.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs have recently emerged as key posttranscriptional regulators of eukaryotic gene expression, yet our understanding of how microRNA expression is itself controlled has remained rudimentary. This review describes recent insights into the mechanisms governing microRNA transcription and processing in vertebrates and their implications for understanding the regulation of microRNA biogenesis.

引用

页码：861 / 865

页数：5

共 35 条

[1] Regulation of flowering time and floral organ identity by a microRNA and its APETALA2-like target genes [J].

Aukerman, MJ ;

Sakai, H .

PLANT CELL, 2003, 15 (11) :2730-2741

[2] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[3] Role for a bidentate ribonuclease in the initiation step of RNA interference [J].

Bernstein, E ;

Caudy, AA ;

Hammond, SM ;

Hannon, GJ .

NATURE, 2001, 409 (6818) :363-366

[4] Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs [J].

Bohnsack, MT ;

Czaplinski, K ;

Görlich, D .

RNA, 2004, 10 (02) :185-191

[5] HASTY, the Arabidopsis ortholog of exportin 5/MSN5, regulates phase change and morphogenesis [J].

Bollman, KM ;

Aukerman, MJ ;

Park, MY ;

Hunter, C ;

Berardini, TZ ;

Poethig, RS .

DEVELOPMENT, 2003, 130 (08) :1493-1504

[6] Trans-splicing and polyadenylation of let-7 microRNA primary transcripts [J].

Bracht, J ;

Hunter, S ;

Eachus, R ;

Weeks, P ;

Pasquinelli, AE .

RNA, 2004, 10 (10) :1586-1594

[7] Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs [J].

Cai, XZ ;

Hagedorn, CH ;

Cullen, BR .

RNA, 2004, 10 (12) :1957-1966

[8] Recognition of a conserved class of RNA tetraloops by Saccharomyces cerevisiae RNase III [J].

Chanfreau, C ;

Buckle, M ;

Jacquier, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3142-3147

[9] Ribonuclease III: new sense from nuisance [J].

Conrad, C ;

Rauhut, R .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2002, 34 (02) :116-129

[10] RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns [J].

Danin-Kreiselman, M ;

Lee, CY ;

Chanfreau, G .

MOLECULAR CELL, 2003, 11 (05) :1279-1289

← 1 2 3 4 →