Novel anti-tuberculosis agents from MCR libraries

被引：31

作者：

Doemling, Alexander

Achatz, Sepp

Beck, Barbara

机构：

[1] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15621 USA

[2] Morphochem AG, Munich, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 19期

关键词：

tuberculosis; multi-component reaction; isocyanide;

D O I：

10.1016/j.bmcl.2007.04.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-based design of libraries of multi-component reaction products yields novel potent anti-tuberculosis compounds. Synthesis and preliminary biological results are presented. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：5483 / 5486

页数：4

共 6 条

[1] Proteome-wide profiling of isoniazid targets in mycobacterium tuberculosis [J].

Argyrou, Argyrides ;

Jin, Lianji ;

Siconilfi-Baez, Linda ;

Angeletti, Ruth H. ;

Blanchard, John S. .

BIOCHEMISTRY, 2006, 45 (47) :13947-13953

[2] INHA, A GENE ENCODING A TARGET FOR ISONIAZID AND ETHIONAMIDE IN MYCOBACTERIUM-TUBERCULOSIS [J].

BANERJEE, A ;

DUBNAU, E ;

QUEMARD, A ;

BALASUBRAMANIAN, V ;

UM, KS ;

WILSON, T ;

COLLINS, D ;

DELISLE, G ;

JACOBS, WR .

SCIENCE, 1994, 263 (5144) :227-230

[3] Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence [J].

Cole, ST ;

Brosch, R ;

Parkhill, J ;

Garnier, T ;

Churcher, C ;

Harris, D ;

Gordon, SV ;

Eiglmeier, K ;

Gas, S ;

Barry, CE ;

Tekaia, F ;

Badcock, K ;

Basham, D ;

Brown, D ;

Chillingworth, T ;

Connor, R ;

Davies, R ;

Devlin, K ;

Feltwell, T ;

Gentles, S ;

Hamlin, N ;

Holroyd, S ;

Hornby, T ;

Jagels, K ;

Krogh, A ;

McLean, J ;

Moule, S ;

Murphy, L ;

Oliver, K ;

Osborne, J ;

Quail, MA ;

Rajandream, MA ;

Rogers, J ;

Rutter, S ;

Seeger, K ;

Skelton, J ;

Squares, R ;

Squares, S ;

Sulston, JE ;

Taylor, K ;

Whitehead, S ;

Barrell, BG .

NATURE, 1998, 393 (6685) :537-+

[4] Recent developments in isocyanide based multicomponent reactions in applied chemistry [J].

Dömling, A .

CHEMICAL REVIEWS, 2006, 106 (01) :17-89

[5] Extreme TB strain threatens HIV victims worldwide [J].

Marris, Emma .

NATURE, 2006, 443 (7108) :131-131

[6] The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis [J].

Somoskovi, A ;

Parsons, LM ;

Salfinger, M .

RESPIRATORY RESEARCH, 2001, 2 (03) :164-168

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