Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD

被引：75

作者：

Wang, J ^{[1
]}

Liu, ZL ^{[1
]}

Chen, B ^{[1
]}

机构：

[1] Sun Yat Sen Univ Med Sci, Affiliated Hosp 1, Dept Neurol, Guangzhou, Peoples R China

来源：

NEUROLOGY | 2001年 / 56卷 / 12期

关键词：

D O I：

10.1212/WNL.56.12.1757

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms, were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor fluctuations in PD.

引用

页码：1757 / 1759

页数：3

共 11 条

[1] A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia [J].

Arinami, T ;

Gao, M ;

Hamaguchi, H ;

Toru, M .

HUMAN MOLECULAR GENETICS, 1997, 6 (04) :577-582

[2] Pharmacogenomics - it's not just pharmacogenetics [J].

Bailey, DS ;

Bondar, A ;

Furness, LM .

CURRENT OPINION IN BIOTECHNOLOGY, 1998, 9 (06) :595-601

[3] Diagnostic criteria for Parkinson disease [J].

Gelb, DJ ;

Oliver, E ;

Gilman, S .

ARCHIVES OF NEUROLOGY, 1999, 56 (01) :33-39

[4] Loss of dopamine uptake sites and dopamine D2 receptors in striatonigral degeneration [J].

González, AM ;

Berciano, J ;

Figols, J ;

Pazos, A ;

Pascual, J .

BRAIN RESEARCH, 2000, 852 (01) :228-232

[5] PCR DETECTION OF THE TAQA RFLP AT THE DRD2 LOCUS [J].

GRANDY, DK ;

ZHANG, Y ;

CIVELLI, O .

HUMAN MOLECULAR GENETICS, 1993, 2 (12) :2197-2197

[6]

Griffon N, 1996, AM J MED GENET, V67, P63, DOI 10.1002/(SICI)1096-8628(19960216)67:1<63::AID-AJMG11>3.0.CO

[7]

2-N

[8] Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers [J].

Jönsson, EG ;

Nöthen, MM ;

Grünhage, F ;

Farde, L ;

Nakashima, Y ;

Propping, P ;

Sedvall, GC .

MOLECULAR PSYCHIATRY, 1999, 4 (03) :290-296

[9]

Lannfelt L., 1992, Psychiatric Genetics, V2, P249, DOI 10.1097/00041444-199210000-00003

[10] Association study of dopamine receptor gene polymorphisms with drug-induced hallucinations in patients with idiopathic Parkinson's disease [J].

Makoff, AJ ;

Graham, JM ;

Arranz, MJ ;

Forsyth, J ;

Li, T ;

Aitchison, KJ ;

Shaikh, S ;

Grünewald, RA .

PHARMACOGENETICS, 2000, 10 (01) :43-48

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