Loss of dopamine uptake sites and dopamine D2 receptors in striatonigral degeneration

被引：10

作者：

González, AM

Berciano, J

Figols, J

Pazos, A

Pascual, J ^{[1
]}

机构：

[1] Univ Hosp Marques Valdecilla, Dept Med, Serv Neurol, Santander 39008, Spain

[2] Univ Hosp Marques Valdecilla, Dept Physiol & Pharmacol, Pharmacol Unit, Santander, Spain

[3] Univ Cantabria, Fac Med, Santander 39008, Spain

[4] Univ Hosp Marques Valdecilla, Sect Neuropathol, Santander, Spain

来源：

BRAIN RESEARCH | 2000年 / 852卷 / 01期

关键词：

dopamine D-2 receptor; dopamine uptake transporter; H-3]nemonapride; Parkinson's disease; striatonigral degeneration; H-3]WIN 35428;

D O I：

10.1016/S0006-8993(99)02205-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To explore the mechanisms underlying L-dopa response, we studied, by postmortem autoradiography, selective makers of dopamine presynaptic terminals, [H-3]WIN 35428, and dopamine D-2 receptors, [H-3]nemonapride, in the putamen of four Parkinson's disease (PD) and one striatonigral degeneration (SND) neuropathologically confirmed brains as compared with six matched control brains. Dopamine uptake transporter was dramatically decreased (>90%) both in PD and SND striatum. Dopamine D-2 receptors were preserved in PD, but clearly reduced (> 6%) in the SND putamen. These data confirm that L-dopa response is closely associated with the preservation of striatal dopamine D-2 receptors, (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：228 / 232

页数：5

相关论文

共 17 条

[1] Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease [J].

Antonini, A ;

Leenders, KL ;

Vontobel, P ;

Maguire, RP ;

Missimer, J ;

Psylla, M ;

Günther, I .

BRAIN, 1997, 120 :2187-2195

[2] DIFFERING PATTERNS OF STRIATAL F-18 DOPA UPTAKE IN PARKINSONS-DISEASE, MULTIPLE SYSTEM ATROPHY, AND PROGRESSIVE SUPRANUCLEAR PALSY [J].

BROOKS, DJ ;

IBANEZ, V ;

SAWLE, GV ;

QUINN, N ;

LEES, AJ ;

MATHIAS, CJ ;

BANNISTER, R ;

MARSDEN, CD ;

FRACKOWIAK, RSJ .

ANNALS OF NEUROLOGY, 1990, 28 (04) :547-555

[3] STRIATAL D2 RECEPTOR STATUS IN PATIENTS WITH PARKINSONS-DISEASE, STRIATONIGRAL DEGENERATION, AND PROGRESSIVE SUPRANUCLEAR PALSY, MEASURED WITH C-11 RACLOPRIDE AND POSITRON EMISSION TOMOGRAPHY [J].

BROOKS, DJ ;

IBANEZ, V ;

SAWLE, GV ;

PLAYFORD, ED ;

QUINN, N ;

MATHIAS, CJ ;

LEES, AJ ;

MARSDEN, CD ;

BANNISTER, R ;

FRACKOWIAK, RSJ .

ANNALS OF NEUROLOGY, 1992, 31 (02) :184-192

[4] DOPA RESISTANCE IN MULTIPLE-SYSTEM ATROPHY - LOSS OF POSTSYNAPTIC D2 RECEPTORS [J].

CHURCHYARD, A ;

DONNAN, GA ;

HUGHES, A ;

HOWELLS, DW ;

WOODHOUSE, D ;

WONG, JYF ;

KALNINS, RM ;

MENDELSOHN, FAO ;

PAXINOS, G .

ANNALS OF NEUROLOGY, 1993, 34 (02) :219-226

[5] DOPAMINE-RECEPTORS IN HUMAN-BRAIN - AUTORADIOGRAPHIC DISTRIBUTION OF D1 AND D2 SITES IN PARKINSON SYNDROME OF DIFFERENT ETIOLOGY [J].

CORTES, R ;

CAMPS, M ;

GUEYE, B ;

PROBST, A ;

PALACIOS, JM .

BRAIN RESEARCH, 1989, 483 (01) :30-38

[6] DOPAMINE-D2 RECEPTOR DENSITY REMAINS CONSTANT IN TREATED PARKINSONS-DISEASE [J].

GUTTMAN, M ;

SEEMAN, P ;

REYNOLDS, GP ;

RIEDERER, P ;

JELLINGER, K ;

TOURTELLOTTE, WW .

ANNALS OF NEUROLOGY, 1986, 19 (05) :487-492

[7] THE DOPAMINERGIC RESPONSE IN MULTIPLE SYSTEM ATROPHY [J].

HUGHES, AJ ;

COLOSIMO, C ;

KLEEDORFER, B ;

DANIEL, SE ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (11) :1009-1013

[8] ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].

HUGHES, AJ ;

DANIEL, SE ;

KILFORD, L ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184

[9]

HUGHES AJ, 1993, ARCH NEUROL-CHICAGO, V50, P1408

[10] THE DOPAMINE TRANSPORTER IS ABSENT IN PARKINSONIAN PUTAMEN AND REDUCED IN THE CAUDATE-NUCLEUS [J].

NIZNIK, HB ;

FOGEL, EF ;

FASSOS, FF ;

SEEMAN, P .

JOURNAL OF NEUROCHEMISTRY, 1991, 56 (01) :192-198