Identification of group I coronavirus antigen in multisystemic granulomatous lesions in ferrets (Mustela putorius furo)

被引：27

作者：

Martinez, J. ^{[1
]}

Reinacher, M. ^{[2
]}

Perpinan, D. ^{[3
]}

Ramis, A. ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Fac Vet, Dept Sanitat & Anat Anim, Barcelona, Spain

[2] Univ Giessen, Inst Vet Pathol, Giessen, Germany

[3] Omahas Henry Doorly Zoo, Omaha, NE USA

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2008年 / 138卷 / 01期

关键词：

coronavirus; feline coronavirus; ferret; granuloma; Mustela putorius furo; viral infection;

D O I：

10.1016/j.jcpa.2007.10.002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Tissues from nine ferrets with granulomatous lesions similar to those seen in feline infectious peritonitis were examined histopathologically and immunohistochemically. Four main types of lesions were observed: diffuse granulomatous inflammation on serosal surfaces; granulomas with areas of necrosis; granulomas without necrosis; and granulomas with neutrophils. Other less commonly seen lesions were granulomatous necrotizing vasculitis and endogenous lipid pneumonia. FCV3-70 monoclonal antibody produced immunolabelling of group I coronavirus antigen in tissue samples from eight animals, the antigen being present in the cytoplasm of macrophages in the different types of granulomatous lesions. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：54 / 58

页数：5

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