Ruthenium(II) complexes with triphosphane ligands combining planar, phosphorus, and carbon chirality: Application to asymmetric reduction of trifluoroacetophenone

被引：14

作者：

Barbaro, P

Bianchini, C

Giambastiani, G

Togni, A

机构：

[1] CNR, Ist Chim Composti Organomet, I-50019 Sesto Fiorentino, Italy

[2] Swiss Fed Inst Technol, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2003年 / 23期

关键词：

asymmetric catalysis; tridentate ligands; ruthenium; hydrogen transfer; chiral ferrocenyls;

D O I：

10.1002/ejic.200300264

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Dichloro-, bis(acetonitrile)chloro-, and tris(acetonitrile)ruthenium(II) complexes with the triphosphane ligands (R)(C)-(S)(Fe)-(S)(P)-P3Chir and (R)(C)-(S)(Fe)-(R)(P)-P3Chir, combining planar, phosphorus, and carbon chirality, were prepared and structurally characterized in solution. The complexes were tested as catalyst precursors for the reduction of trifluoroacetophenone to (R)-alpha-(trifluoromethyl)benzyl alcohol by either hydrogenation or hydrogen transfer from iPrOH. The best conversion and enantioselectivity was obtained with the tris(acetonitrile) precursor [{(R)(C)-(S)(Fe)-(S)(P)-P3Chir}Ru(CH3CN)(3)](PF6)(2) in hydrogen-transfer conditions using a basic co-catalyst. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

引用

页码：4166 / 4172

页数：7

共 69 条

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