Use and misuse of the gene ontology annotations

被引：340

作者：

Rhee, Seung Yon ^{[1
]}

Wood, Valerie ^{[2
]}

Dolinski, Kara ^{[3
]}

Draghici, Sorin ^{[4
]}

机构：

[1] Carnegie Inst Sci, Dept Plant Biol, Stanford, CA 94305 USA

[2] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[3] Princeton Univ, Carl Icahn Lab, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

[4] Wayne State Univ, Dept Comp Sci, Detroit, MI 48202 USA

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 07期

关键词：

D O I：

10.1038/nrg2363

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Gene Ontology (GO) project is a collaboration among model organism databases to describe gene products from all organisms using a consistent and computable language. GO produces sets of explicitly defined, structured vocabularies that describe biological processes, molecular functions and cellular components of gene products in both a computer-and human-readable manner. Here we describe key aspects of GO, which, when overlooked, can cause erroneous results, and address how these pitfalls can be avoided.

引用

页码：509 / 515

页数：7