Desorption electrospray ionization mass spectrometry for lipid characterization and biological tissue imaging

被引：210

作者：

Eberlin, Livia S.

Ferreira, Christina R.

Dill, Allison L.

Ifa, Demian R.

Cooks, R. Graham ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2011年 / 1811卷 / 11期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Ambient mass spectrometry; Imaging; Lipidomics; Disease diagnosis; Desorption electrospray ionization; Lipid characterization; FATTY-ACID COMPOSITIONS; CHOLESTEROL SULFATE; INFILTRATING LESIONS; PARTIAL SEPARATION; PHOSPHOLIPIDS; CANCER; BRAIN; DESI; PROFILES; CELLS;

D O I：

10.1016/j.bbalip.2011.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Desorption electrospray ionization mass spectrometry (DESI-MS) imaging of biological samples allows untargeted analysis and structural characterization of lipids ionized from the near-surface region of a sample under ambient conditions. DESI is a powerful and sensitive MS ionization method for 2D and 3D imaging of lipids from direct and unmodified complex biological samples. This review describes the strengths and limitations of DESI-MS for lipid characterization and imaging together with the technical workflow and a survey of applications. Included are discussions of lipid mapping and biomarker discovery as well as a perspective on the future of DESI imaging. (C) 2011 Elsevier B.V. All rights reserved.

引用

收藏

页码：946 / 960

页数：15

相关论文

共 97 条

[1] Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery [J].

Agar, Nathalie Y. R. ;

Golby, Alexandra J. ;

Ligon, Keith L. ;

Norton, Isaiah ;

Mohan, Vandana ;

Wiseman, Justin M. ;

Tannenbaum, Allen ;

Jolesz, Ferenc A. .

NEUROSURGERY, 2011, 68 (02) :280-290

[2] Fatty acid patterns in gastric mucosa of stomach cancer patients [J].

Ahn, J ;

Park, IS ;

Lee, SK ;

Kim, SY ;

Chung, EJ ;

Kim, J ;

Kim, DJ ;

Yoon, S ;

Lee-Kim, YC .

YONSEI MEDICAL JOURNAL, 2001, 42 (02) :220-226

[3] Ambient mass spectrometry: bringing MS into the "real world" [J].

Alberici, Rosana M. ;

Simas, Rosineide C. ;

Sanvido, Gustavo B. ;

Romao, Wanderson ;

Lalli, Priscila M. ;

Benassi, Mario ;

Cunha, Ildenize B. S. ;

Eberlin, Marcos N. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 398 (01) :265-294

[4] Enhanced Ion Signals in Desorption Electrospray Ionization Using Surfactant Spray Solutions [J].

Badu-Tawiah, Abraham ;

Cooks, R. Graham .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2010, 21 (08) :1423-1431

[5] Non-Aqueous Spray Solvents and Solubility Effects in Desorption Electrospray Ionization [J].

Badu-Tawiah, Abraham ;

Bland, Celine ;

Campbell, Dahlia I. ;

Cooks, R. Graham .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2010, 21 (04) :572-579

[6] Analysis of lipids from crude lung tissue extracts by desorption electrospray ionization mass spectrometry and pattern recognition [J].

Basile, Franco ;

Sibray, Tamara ;

Belisle, John T. ;

Bowen, Richard A. .

ANALYTICAL BIOCHEMISTRY, 2011, 408 (02) :289-296

[7] Monitoring of Biochemical Changes through the C6 Gliomas Progression and Invasion by Fourier Transform Infrared (FTIR) Imaging [J].

Beljebbar, Abdelilah ;

Dukic, Sylvain ;

Amharref, Nadia ;

Bellefqih, Salima ;

Manfait, Michel .

ANALYTICAL CHEMISTRY, 2009, 81 (22) :9247-9256

[8] Electrospray ionization tandem mass spectrometry of glycerophosphoethanolamine plasmalogen phospholipids [J].

Berry, KAZ ;

Murphy, RC .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2004, 15 (10) :1499-1508

[9] Advances in Mass Spectrometry for Lipidomics [J].

Blanksby, Stephen J. ;

Mitchell, Todd W. .

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 3, 2010, 3 :433-465

[10] Advances in Imaging Secondary Ion Mass Spectrometry for Biological Samples [J].

Boxer, Steven G. ;

Kraft, Mary L. ;

Weber, Peter K. .

ANNUAL REVIEW OF BIOPHYSICS, 2009, 38 :53-74

← 1 2 3 4 5 6 7 8 9 10 →