Bioinorganic models for the catalytic cooperation of metal ions and functional groups in nuclease and peptidase enzymes

被引：176

作者：

Krämer, R ^{[1
]}

机构：

[1] Univ Munster, Inst Anorgan Chem, D-48149 Munster, Germany

来源：

COORDINATION CHEMISTRY REVIEWS | 1999年 / 182卷

关键词：

peptidases; enzymes; catalysis;

D O I：

10.1016/S0010-8545(98)00235-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Many nuclease and peptidase enzymes achieve highly efficient catalysis by active site cooperation of metal ions and amino acid side chains (acids, bases or nucleophiles). This review focuses on model complexes for which attachment of functional organic groups to a chelate ligand results in an increased hydrolytic reactivity toward phosphodiesters and amides. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：243 / 261

页数：19

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