Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity

被引：360

作者：

Ohno, S ^{[1
]}

机构：

[1] Yokohama City Univ, Sch Med, Dept Mol Biol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(00)00264-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Two PDZ-domain-containing adapter-like proteins, PAR-3 and PAR-6, and a protein kinase, atypical protein kinase C (PKC), cooperate together to establish cell polarity in a variety of biological contexts. These include asymmetric cell division in early Caenorhabditis elegans embryo and Drosophila neuroblasts, as well as the establishment and maintenance of apical-basal polarity in Drosophila and mammalian epithelial cells. Recent studies on the role of this PAR-aPKC complex in epithelia[ cell polarization provide new insights into the molecular basis of epithelial junctional formation and cell polarity.

引用

页码：641 / 648

页数：8

共 67 条

[1] EGF or PDGF receptors activate atypical PKC lambda through phosphatidylinositol 3-kinase [J].

Akimoto, K ;

Takahashi, R ;

Moriya, S ;

Nishioka, N ;

Takayanagi, J ;

Kimura, K ;

Fukui, Y ;

Osada, S ;

Mizuno, K ;

Hirai, S ;

Kazlauskas, A ;

Ohno, S .

EMBO JOURNAL, 1996, 15 (04) :788-798

[2] Mutations in ooc-5 and ooc-3 disrupt oocyte formation and the reestablishment of asymmetric PAR protein localization in two-cell Caenorhabditis elegans embryos [J].

Basham, SE ;

Rose, LS .

DEVELOPMENTAL BIOLOGY, 1999, 215 (02) :253-263

[3] Cell polarity: Squaring the circle [J].

Bilder, D .

CURRENT BIOLOGY, 2001, 11 (04) :R132-R135

[4] Mammalian homologues of C-elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity [J].

Bohm, H ;

Brinkmann, V ;

Drab, M ;

Henske, A ;

Kurzchalia, TV .

CURRENT BIOLOGY, 1997, 7 (08) :603-606

[5] Cell polarity in the early Caenorhabditis elegans embryo [J].

Bowerman, B ;

Shelton, CA .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (04) :390-395

[6]

Boyd L, 1996, DEVELOPMENT, V122, P3075

[7] Drosophila par-1 is required for oocyte differentiation and microtubule organization [J].

Cox, DN ;

Lu, BW ;

Sun, TQ ;

Williams, LT ;

Jan, YN .

CURRENT BIOLOGY, 2001, 11 (02) :75-87

[8] Asymmetric cell division: fly neuroblast meets worm zygote [J].

Doe, CQ ;

Bowerman, B .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (01) :68-75

[9] MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption [J].

Drewes, G ;

Ebneth, A ;

Preuss, U ;

Mandelkow, EM ;

Mandelkow, E .

CELL, 1997, 89 (02) :297-308

[10] Origins of cell polarity [J].

Drubin, DG ;

Nelson, WJ .

CELL, 1996, 84 (03) :335-344

← 1 2 3 4 5 6 7 →