Cystatin C is not a better estimator of GFR than plasma creatinine in the general population

被引:107
作者
Eriksen, Bjorn O. [1 ,2 ]
Mathisen, Ulla D. [1 ,2 ]
Melsom, Toralf [1 ,2 ]
Ingebretsen, Ole C. [3 ,4 ]
Jenssen, Trond G. [2 ,5 ]
Njolstad, Inger [6 ]
Solbu, Marit D. [1 ]
Toft, Ingrid [1 ,2 ]
机构
[1] Univ Hosp N Norway, Nephrol Sect, Clin Internal Med, N-9038 Tromso, Norway
[2] Univ Tromso, Dept Clin Med, Tromso, Norway
[3] Univ Hosp N Norway, Dept Med Biochem, N-9038 Tromso, Norway
[4] Univ Tromso, Dept Med Biol, Tromso, Norway
[5] Oslo Univ Hosp, Rikshosp, Med Sect, Dept Internal Med, Oslo, Norway
[6] Univ Tromso, Dept Community Med, Tromso, Norway
关键词
cardiovascular disease; clinical nephrology; Cockcroft-Gault; creatinine; glomerular filtration rate; GLOMERULAR-FILTRATION-RATE; COCKCROFT-GAULT EQUATIONS; CHRONIC KIDNEY-DISEASE; SERUM CREATININE; RENAL-DISEASE; PREDICTION EQUATIONS; CLEARANCE; DIET; SINGLE; VALUES;
D O I
10.1038/ki.2010.321
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Accurate measurement of glomerular filtration rate (GFR) is complicated and costly; therefore, GFR is commonly estimated by assessing creatinine or cystatin C concentrations. Because estimates based on cystatin C predict cardiovascular disease better than creatinine, these estimates have been hypothesized to be superior to those based on creatinine, when the GFR is near the normal range. To test this, we measured GFR by iohexol clearance in a representative sample of middle-aged (50-62 years) individuals in the general population, excluding those with coronary heart or kidney disease, stroke or diabetes mellitus. Bias, precision (median and interquartile range of estimated minus measured GFR (mGFR)), and accuracy (percentage of estimates within 30% of mGFR) of published cystatin C and creatinine-based GFR equations were compared in a total of 1621 patients. The cystatin C-based equation with the highest accuracy (94%) had a bias of 3.5 and precision of 18 ml/min per 1.73 m(2), whereas the most accurate (95%) creatinine-based equation had a bias of 2.9 and precision of 15 ml/min per 1.73 m(2). The best equation, based on both cystatin C and creatinine, had a bias of 7.6 ml/min per 1.73 m(2), precision of 15 ml/min per 1.73 m(2), and accuracy of 92%. Thus, estimates of GFR based on cystatin C were not superior to those based on creatinine in the general population. Hence, the better prediction of cardiovascular disease by cystatin C than creatinine measurements, found by others, may be due to factors other than GFR. Kidney International (2010) 78, 1305-1311; doi:10.1038/ki.2010.321; published online 15 September 2010
引用
收藏
页码:1305 / 1311
页数:7
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