Long-chain N-acylethanolamines inhibit lipid peroxidation in rat liver mitochondria under acute hypoxic hypoxia

被引：35

作者：

Gulaya, NM ^{[1
]}

Kuzmenko, AI ^{[1
]}

Margitich, VM ^{[1
]}

Govseeva, NM ^{[1
]}

Melnichuk, SD ^{[1
]}

Goridko, TM ^{[1
]}

Zhukov, AD ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, OV Palladin Biochem Inst, UA-252030 Kiev, Ukraine

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1998年 / 97卷 / 01期

关键词：

N-acylethanolamines; lipid peroxidation; hypoxia; chemiluminescence; free radicals;

D O I：

10.1016/S0009-3084(98)00093-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two long-chain N-acylethanolamines (NAEs:), N-palmitoyl- (NPE) and N-stearoylethanolamine (NSE), are shown to inhibit an in vitro non-enzymatic Fe2+-induced free radical oxidation of lipids in the liver mitochondria of rats with hypoxic hypoxia. NSE appeared to be more effective than NPE in suppressing some kinetic parameters of the Fe2+-induced chemiluminescence. The inhibitory action of NAEs on non-enzymatic lipid peroxidation supports the idea that they possess membrane protective properties. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：49 / 54

页数：6

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