Prenatal exposure to a farm environment modifies atopic sensitization at birth

被引:131
作者
Ege, Markus Johannes [1 ]
Herzum, Ileana [2 ]
Buechele, Gisela [3 ]
Krauss-Etschmann, Susanne [1 ,4 ]
Lauener, Roger P. [5 ]
Roponen, Marjut [6 ]
Hyvaerinen, Anne [6 ]
Vuitton, Dominique A. [7 ]
Riedler, Josef [8 ]
Brunekreef, Bert [9 ,10 ]
Dalphin, Jean-Charles [11 ]
Braun-Fahrlaender, Charlotte [12 ]
Pekkanen, Juha [6 ,13 ]
Renz, Harald [2 ]
von Mutius, Erika [1 ]
机构
[1] Univ Childrens Hosp, Munich, Germany
[2] Univ Marburg, Dept Clin Chem & Mol Diagnost, Marburg, Germany
[3] Univ Ulm, Inst Epidemiol, Ulm, Germany
[4] HelmholtzZentrum Munchen German Res Ctr Environm, Munich, Germany
[5] Univ Zurich, Childrens Hosp, Zurich, Switzerland
[6] Natl Publ Hlth Inst, Dept Environm Hlth, Kuopio, Finland
[7] Univ Franche Comte, SERF Res Unit, F-25030 Besancon, France
[8] Childrens Hosp, Schwarzach, Austria
[9] Univ Med Ctr Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands
[10] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
[11] Univ Hosp, Dept Resp Dis, Besancon, France
[12] Univ Basel, Inst Social & Prevent Med, Basel, Switzerland
[13] Univ Kuopio, Sch Publ Hlth & Clin Nutr, FIN-70211 Kuopio, Finland
关键词
prenatal exposure; atopic sensitization; cord blood; farming; microbial components;
D O I
10.1016/j.jaci.2008.06.011
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Previous cross-sectional surveys have suggested that maternal exposure to animal sheds during pregnancy exerted a protective effect on atopic sensitization in children lasting until school age. Objective: We sought to evaluate the effects of maternal exposure to animal sheds and other farm-related exposures during pregnancy on cord blood IgE levels in a prospective birth cohort. Methods: Pregnant women living in rural areas in Austria, Finland, France, Germany, and Switzerland were recruited in the third trimester of pregnancy. Information on maternal farm-related exposures, nutrition, and health during pregnancy was obtained by means of interviews. Specific IgE levels for food and common inhalant allergens were assessed in cord blood of 922 children and peripheral blood samples of their mothers. Results: Different sensitization patterns in cord blood of farm and nonfarm children were observed. In multivariable analysis consumption of boiled, but not unboiled, farm milk during pregnancy was positively associated with specific IgE to cow's milk independently from maternal IgE. In contrast, there was an inverse relationship between maternal exposure to animal sheds and cord blood IgE levels against seasonal allergens (adjusted odds ratio, 0.38; 95% CI, 0.21-0.70). This association was not confounded by maternal IgE levels. Maternal contact with hay enhanced the protective effect of exposure to animal sheds on IgE levels to grass pollen in cord blood.
引用
收藏
页码:407 / 412
页数:6
相关论文
共 27 条
[1]   Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle -: the PARSIFAL study [J].
Alfvén, T ;
Braun-Fahrländer, C ;
Brunekreef, B ;
von Mutius, E ;
Riedler, J ;
Scheynius, A ;
van Hage, M ;
Wickman, M ;
Benz, MR ;
Budde, J ;
Michels, KB ;
Schram, D ;
Üblagger, E ;
Waser, M ;
Pershagen, G .
ALLERGY, 2006, 61 (04) :414-421
[2]   INTERNATIONAL STUDY OF ASTHMA AND ALLERGIES IN CHILDHOOD (ISAAC) - RATIONALE AND METHODS [J].
ASHER, MI ;
KEIL, U ;
ANDERSON, HR ;
BEASLEY, R ;
CRANE, J ;
MARTINEZ, F ;
MITCHELL, EA ;
PEARCE, N ;
SIBBALD, B ;
STEWART, AW ;
STRACHAN, D ;
WEILAND, SK ;
WILLIAMS, HC .
EUROPEAN RESPIRATORY JOURNAL, 1995, 8 (03) :483-491
[3]   Sensitization does not develop in utero [J].
Bonnelykke, Klaus ;
Pipper, Christian Bressen ;
Bisgaard, Hans .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 121 (03) :646-651
[4]   Can allergic diseases be prevented prenatally? [J].
Boyle, R. J. ;
Tang, M. L. K. .
ALLERGY, 2006, 61 (12) :1423-1431
[5]   Fungal extracellular polysaccharides in house dust as a marker for exposure to fungi: Relations with culturable fungi, reported home dampness, and respiratory symptoms [J].
Douwes, J ;
van der Sluis, B ;
Doekes, G ;
van Leusden, F ;
Wijnands, L ;
van Strien, R ;
Verhoeff, A ;
Brunekreef, B .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (03) :494-500
[6]   INFLUENCE OF VARIOUS DUST SAMPLING AND EXTRACTION METHODS ON THE MEASUREMENT OF AIRBORNE ENDOTOXIN [J].
DOUWES, J ;
VERSLOOT, P ;
HOLLANDER, A ;
HEEDERIK, D ;
DOEKES, G .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1995, 61 (05) :1763-1769
[7]   Not all farming environments protect against the development of asthma and wheeze in children [J].
Ege, Markus Johannes ;
Frei, Remo ;
Bieli, Christian ;
Schram-Bijkerk, Dieneke ;
Waser, Marco ;
Benz, Marcus R. ;
Weiss, Gertraud ;
Nyberg, Fredrik ;
van Hage, Marianne ;
Pershagen, Goeran ;
Brunekreef, Bert ;
Riedler, Josef ;
Lauener, Roger ;
Braun-Fahrlaender, Charlotte ;
von Mutius, Erika .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (05) :1140-1147
[8]   Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children [J].
Ege, MJ ;
Bieli, C ;
Frei, R ;
van Strien, RT ;
Riedler, J ;
Üblagger, E ;
Schram-Bijkerk, D ;
Brunekreef, B ;
van Hage, M ;
Scheynius, A ;
Pershagen, G ;
Benz, MR ;
Lauener, R ;
von Mutius, E ;
Braun-Fahrländer, C .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (04) :817-823
[9]  
FERRIS BG, 1978, AM REV RESPIR DIS, V118, P1
[10]   Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life [J].
Hagendorens, MM ;
Ebo, DG ;
Bridts, CH ;
Van de Water, L ;
De Clerck, LS ;
Stevens, WJ .
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2004, 15 (04) :308-315