Diacylglycerol - when is it an intracellular messenger?

被引：153

作者：

Wakelam, MJO ^{[1
]}

机构：

[1] Univ Birmingham, Queen Elizabeth Hosp, Inst Canc Studies, Birmingham B15 2TA, W Midlands, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 1998年 / 1436卷 / 1-2期

基金：

英国惠康基金;

关键词：

diacylglycerol; phosphatidate; protein kinase C; phospholipase C; phospholipase D;

D O I：

10.1016/S0005-2760(98)00123-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Distinct, structurally different forms of sn-1,2-diacylglycerol are found in cells, these are polyunsaturated, mono- or diunsaturated and saturated. The pathways that generate or metabolise sn-1,2-diacylglycerol are reviewed. The evidence that it is the polyunsaturated forms of sn-1,2-diacylglycerol,but the more saturated forms of phosphatidate which function as intracellular signals is considered. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：117 / 126

页数：10

共 98 条

[1] Nuclear translocation of RhoA mediates the mitogen-induced activation of phospholipase D involved in nuclear envelope signal transduction
Baldassare, JJ
Jarpe, MB
Alferes, L
Raben, DM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (08) : 4911 - 4914
[2] INOSITOL PHOSPHATES AND CELL SIGNALING
BERRIDGE, MJ
IRVINE, RF
[J]. NATURE, 1989, 341 (6239) : 197 - 205
[3] RAPID FORMATION OF DIACYLGLYCEROL FROM PHOSPHATIDYLCHOLINE - A PATHWAY FOR GENERATION OF A 2ND MESSENGER
BESTERMAN, JM
DURONIO, V
CUATRECASAS, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (18) : 6785 - 6789
[4] Phosphatidic acid formation Toy phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex
Bi, K
Roth, G
Ktistakis, NT
[J]. CURRENT BIOLOGY, 1997, 7 (05) : 301 - 307
[5] THE REGULATION AND CELLULAR FUNCTIONS OF PHOSPHATIDYLCHOLINE HYDROLYSIS
BILLAH, MM
ANTHES, JC
[J]. BIOCHEMICAL JOURNAL, 1990, 269 (02) : 281 - 291
[6] BOCCKINO SB, 1985, J BIOL CHEM, V260, P4201
[7] Phosphatidate phosphohydrolase and signal transduction
Brindley, DN
Waggoner, DW
[J]. CHEMISTRY AND PHYSICS OF LIPIDS, 1996, 80 (1-2) : 45 - 57
[8] Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation
Brown, FD
Thompson, N
Saqib, KM
Clark, JM
Powner, D
Thompson, NT
Solari, R
Wakelam, MJO
[J]. CURRENT BIOLOGY, 1998, 8 (14) : 835 - 838
[9] Molecular cloning and characterization of a novel human diacylglycerol kinase zeta
Bunting, M
Tang, W
Zimmerman, GA
McIntyre, TM
Prescott, SM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (17) : 10230 - 10236
[10] HYDROLYSIS OF PHOSPHATIDYLCHOLINE IS STIMULATED BY RAS PROTEINS DURING MITOGENIC SIGNAL TRANSDUCTION
CAI, H
ERHARDT, P
SZEBERENYI, J
DIAZMECO, MT
JOHANSEN, T
MOSCAT, J
COOPER, GM
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (12) : 5329 - 5335

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