Regioselective rhodium-catalyzed allylic alkylation/ring-closing metathesis approach to carbocycles

被引：22

作者：

Evans, PA ^{[1
]}

Kennedy, LJ

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

[2] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 40期

基金：

美国国家卫生研究院;

关键词：

rhodium-catalyzed; allylic alkylation; metathesis; vicinal quaternary and ternary carbon stereogenic carbons;

D O I：

10.1016/S0040-4039(01)01467-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of the allylic carbonates 1a-c with the sodium anion of the alpha -substsituted malonates (n=0-2) and Wilkinson's catalyst modified with with a triorganophosphite, furnished the allylic alkylation products 2/3a-1 in 83 97% yield, favoring 2a-i. The dienes 2a-i were then subjected to ring-closing metathesis using either I or II. to afford the carbocycles 4a-i in 79-99% yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7015 / 7018

页数：4

共 33 条

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[3]

2-V

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