Definitions and outcome measures for bullous pemphigoid: Recommendations by an international panel of experts

被引：309

作者：

Murrell, Dedee F. ^{[1
]}

Daniel, Benjamin S. ^{[1
]}

Joly, Pascal ^{[2
]}

Borradori, Luca ^{[3
]}

Amagai, Masayuki ^{[4
]}

Hashimoto, Takashi ^{[5
]}

Caux, Frederic ^{[6
]}

Marinovic, Branka ^{[7
]}

Sinha, Animesh A. ^{[8
]}

Hertl, Michael ^{[9
]}

Bernard, Philippe ^{[32
]}

Sirois, David ^{[10
]}

Cianchini, Giuseppe ^{[11
]}

Fairley, Janet A. ^{[13
,14
]}

Jonkman, Marcel F. ^{[15
]}

Pandya, Amit G. ^{[17
]}

Rubenstein, David ^{[16
]}

Zillikens, Detlef ^{[18
]}

Payne, Aimee S. ^{[20
]}

Woodley, David ^{[19
]}

Zambruno, Giovanna ^{[12
]}

Aoki, Valeria ^{[21
]}

Pincelli, Carlo ^{[22
]}

Diaz, Luis ^{[16
]}

Hall, Russell P. ^{[23
]}

Meurer, Michael ^{[25
]}

Mascaro, Jose M., Jr. ^{[26
]}

Schmidt, Enno ^{[18
]}

Shimizu, Hiroshi ^{[24
]}

Zone, John ^{[27
]}

Swerlick, Robert ^{[29
]}

Mimouni, Daniel ^{[31
]}

Culton, Donna ^{[16
]}

Lipozencic, Jasna ^{[7
]}

Bince, Benjamin ^{[28
]}

Grando, Sergei A. ^{[33
,34
]}

Bystryn, Jean-Claude ^{[30
]}

Werth, Victoria P. ^{[20
,35
]}

机构：

[1] Univ New S Wales, St George Hosp, Dept Dermatol, Sydney, NSW, Australia

[2] Univ Rouen, Rouen Univ Hosp, Dermatol Clin, Dept Dermatol,INSERM,U905, F-76821 Mont St Aignan, France

[3] Univ Hosp Bern, Dept Dermatol, Bern, Switzerland

[4] Keio Univ, Sch Med, Tokyo, Japan

[5] Kurume Univ, Sch Med, Kurume, Fukuoka, Japan

[6] Univ Paris 08, Dept Dermatol, Bobigny, France

[7] Univ Zagreb, Hosp Ctr & Sch Med, Dept Dermatol & Venereol, Zagreb 41000, Croatia

[8] SUNY Buffalo, Dept Dermatol, Buffalo, NY 14260 USA

[9] Univ Hosp, Dept Dermatol, Marburg, Germany

[10] NYU, Coll Dent, Dept Oral Med, New York, NY 10003 USA

[11] IRCCS, Inst Dermopat Immacolata, Immunodermatol Dept, Rome, Italy

[12] IRCCS, Inst Dermopat Immacolata, Lab Mol & Cell Biol, Rome, Italy

[13] Univ Iowa, Dept Dermatol, Iowa City, IA USA

[14] Dept Vet Affairs Med Ctr, Iowa City, IA 52242 USA

[15] Univ Groningen, Univ Med Ctr Groningen, NL-9700 AB Groningen, Netherlands

[16] Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27514 USA

[17] Univ Texas SW Med Ctr Dallas, Dallas, TX USA

[18] Univ Lubeck, Dept Dermatol, Lubeck, Germany

[19] Univ So Calif, Dept Dermatol, Keck Sch Med, Los Angeles, CA 90089 USA

[20] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA

[21] Univ Sao Paulo, Dept Dermatol, BR-05508 Sao Paulo, Brazil

[22] Univ Modena & Reggio Emilia, Inst Dermatol, Sch Biosci & Biotechnol, Modena, Italy

[23] Duke Med Ctr, Div Dermatol, Durham, NC USA

[24] Hokkaido Univ, Grad Sch Med, Dept Dermatol, Sapporo, Hokkaido, Japan

[25] Tech Univ Dresden, Carl Gustav Carus Med Sch, Dresden, Germany

[26] Univ Barcelona, Dept Dermatol, E-08007 Barcelona, Spain

[27] Univ Utah, Dept Dermatol, Salt Lake City, UT 84112 USA

[28] Jose R Reyes Mem Med Ctr, Dept Dermatol, Manila, Philippines

[29] Emory Univ, Sch Med, Dept Dermatol, Atlanta, GA 30322 USA

[30] NYU, Med Ctr, New York, NY 10003 USA

[31] Rabin Med Ctr, Dept Dermatol, Petah Tiqwa, Israel

[32] Robert Debre Univ Hosp, Dept Dermatol, Reims, France

[33] Univ Calif Irvine, Dept Biol Chem, Dept Dermatol, Ctr Canc, Irvine, CA 92717 USA

[34] Univ Calif Irvine, Res Inst, Inst Immunol, Irvine, CA USA

[35] Philadelphia Dept Vet Affairs Med Ctr, Philadelphia, PA USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2012年 / 66卷 / 03期

基金：

美国国家卫生研究院;

关键词：

bullous pemphigoid; consensus; definitions; outcome measures; severity score; TOPICAL CORTICOSTEROIDS;

D O I：

10.1016/j.jaad.2011.06.032

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Our scientific knowledge of bullous pemphigoid (BP) has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in BP. A major obstacle in sharing multicenter-based evidences for therapeutic efforts is the lack of generally accepted definitions for the clinical evaluation of patients with BP. Common terms and end points of BP are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials. These recommendations from the International Pemphigoid Committee represent 2 years of collaborative efforts to attain mutually acceptable common definitions for BP and proposes a disease extent score, the BP Disease Area Index. These items should assist in the development of consistent reporting of outcomes in future BP reports and studies. (J Am Acad Dermatol 2012;66:479-85.)

引用

页码：479 / 485

页数：7

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