Stra13, a basic helix-loop-helix transcription factor, is up-regulated upon activation of CD4(+) T cells. Here we show that Stra13-deficient mice exhibit defects in several phases of CD4(+) T cell activation. In vivo, Stra13 deficiency results in ineffective elimination of activated T and B cells, which accumulate progressively, leading to lymphoid organ hyperplasia. Consequently, aging Stra13(-/-) mice develop autoimmune disease characterized by accumulation of spontaneously activated T and B cells, circulating autoantibodies, infiltration of T and B lymphocytes in several organs and immune complex deposition in glomeruli. Our studies identify Stra13 as a key regulator of lymphocyte activation that is vital for maintenance of self-tolerance and for constraint of autoimmunity.
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La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Kasibhatla, S
Brunner, T
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La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Brunner, T
Genestier, L
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La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Genestier, L
Echeverri, F
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La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Echeverri, F
Mahboubi, A
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La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Mahboubi, A
Green, DR
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La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
机构:
La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Kasibhatla, S
Brunner, T
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h-index: 0
机构:
La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Brunner, T
Genestier, L
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h-index: 0
机构:
La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Genestier, L
Echeverri, F
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La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Echeverri, F
Mahboubi, A
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机构:
La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Mahboubi, A
Green, DR
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h-index: 0
机构:
La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA