Saliva of hematophagous insects: a multifaceted toolkit

被引：55

作者：

Arca, Bruno ^{[1
]}

Ribeiro, Jose M. C. ^{[2
]}

机构：

[1] Sapienza Univ, Dept Publ Hlth & Infect Dis, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[2] NIAID, Lab Malaria & Vector Res, 12735 Twinbrook Pkwy, Rockville, MD 20852 USA

来源：

CURRENT OPINION IN INSECT SCIENCE | 2018年 / 29卷

关键词：

FLY LUTZOMYIA-LONGIPALPIS; PROTEIN; COMPLEMENT; ACTIVATION; INHIBITOR; EVOLUTION; BINDING; SYSTEM; EXPRESSION; BIOMARKERS;

D O I：

10.1016/j.cois.2018.07.012

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Transcriptomic, proteomic and genomic studies significantly improved our understanding of the complexity of blood feeding insect saliva providing unparalleled evolutionary insights. Salivary genes appeared to be under strong selective pressure with gene duplication and functional diversification being a powerful driver in the evolution of novel salivary genes/functions. The first insect salivary proteins responsible for complement inhibition were identified and a widespread mechanism of action shared by unrelated salivary protein families was recognized and named kratagonism. microRNAs were for the first time described in the saliva of a few blood feeding arthropods raising intriguing questions on their possible contribution to vertebrate host manipulation and pathogen transmission and further emphasizing how much we still have to learn on blood feeding insect saliva.

引用

页码：102 / 109

页数：8

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