Direct β-alkylation of secondary alcohols with primary alcohols catalyzed by a Cp*lr complex

被引：205

作者：

Fujita, K ^{[1
]}

Asai, C ^{[1
]}

Yamaguchi, T ^{[1
]}

Hanasaka, F ^{[1
]}

Yamaguchi, R ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Human & Environm Studies, Sakyo Ku, Kyoto 6068501, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 18期

关键词：

D O I：

10.1021/ol051517o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new catalytic system for beta-alkylation of secondary alcohols has been developed. In the presence of [Cp*IrCl2](2) (CP* = pentamethylcyclopentadienyl) catalyst and base, the reactions of various secondary alcohols with primary alcohols give beta-alkylated higher alcohols in good to excellent yields without any hydrogen acceptor or hydrogen donor. This reaction proceeds via successive hydrogen-transfer reactions and aldol condensation.

引用

页码：4017 / 4019

页数：3

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