Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats

被引：121

作者：

Watanabe, TK

Katagiri, T

Suzuki, M

Shimizu, F

Fujiwara, T

Kanemoto, N

Nakamura, Y

Hirai, Y

Maekawa, H

Takahashi, E

机构：

[1] OTSUKA PHARMACEUT CO LTD,OTSUKA GEN RES INST,TOKUSHIMA 77101,JAPAN

[2] JAPANESE FDN CANC RES,CTR CANC CHEMOTHERAPY,DIV HUMAN GENOME ANAL,TOSHIMA KU,TOKYO 170,JAPAN

[3] TOTTORI UNIV,FAC MED,SCH LIFE SCI,DEPT MOL & CELL GENET,YONAGO,TOTTORI 683,JAPAN

[4] UNIV TOKYO,INST MED SCI,MOL MED LAB,MINATO KU,TOKYO 108,JAPAN

来源：

GENOMICS | 1996年 / 38卷 / 03期

关键词：

D O I：

10.1006/geno.1996.0628

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

From a human fetal-brain cDNA library we isolated two novel genes encoding peptides containing six EGF-like repeats. Both showed significant homologies with nel, a gene strongly expressed in neural tissues of chicken. The cDNAs, designated NELL1 (nel-like, type 1) and NELL2 (nel-like, type 2), contained open reading frames encoding 810 and 816 amino acids, respectively. NELL2 is strongly expressed in brain of adult and fetus but only weakly in fetal kidney. NELL1 and NELL2 were mapped by FISH to chromosomal bands 11p15.1-p15.2 and 12q13.11-q13.2, respectively. (C) 1996 Academic Press, Inc.

引用

页码：273 / 276

页数：4

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