An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: Interaction with several nuclear receptors

被引：51

作者：

Masuda, N ^{[1
]}

Yasumo, H ^{[1
]}

Tamura, T ^{[1
]}

Hashiguchi, N ^{[1
]}

Furusawa, T ^{[1
]}

Tsukamoto, T ^{[1
]}

Sadano, H ^{[1
]}

Osumi, T ^{[1
]}

机构：

[1] HIMEJI INST TECHNOL,FAC SCI,DEPT LIFE SCI,KAMIGORI,HYOGO 67812,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1997年 / 1350卷 / 01期

关键词：

nuclear hormone receptor; orphan nuclear receptor; two-hybrid system; heterodimer formation;

D O I：

10.1016/S0167-4781(96)00196-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The yeast two-hybrid screening was applied to cloning cDNAs of proteins that interact with peroxisome proliferator-activated receptor alpha (PPAR alpha). We obtained from a rat liver cDNA library a clone encoding a protein related to the ligand-binding domain of the members of nuclear hormone receptor superfamily, whereas apparently lacking the zinc-finger DNA-binding domain. This protein interacted with the activated forms of several nuclear receptors, and thus is a novel type of heterodimer-forming nuclear receptor.

引用

页码：27 / 32

页数：6

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