NUCLEAR FACTOR RIP140 MODULATES TRANSCRIPTIONAL ACTIVATION BY THE ESTROGEN-RECEPTOR

被引：652

作者：

CAVAILLES, V

DAUVOIS, S

LHORSET, F

LOPEZ, G

HOARE, S

KUSHNER, PJ

PARKER, MG

机构：

[1] IMPERIAL CANC RES FUND, MOLEC ENDOCRINOL LAB, LONDON WC2A 3PX, ENGLAND

[2] UNIV CALIF SAN FRANCISCO, METAB RES UNIT, SAN FRANCISCO, CA 94143 USA

来源：

EMBO JOURNAL | 1995年 / 14卷 / 15期

关键词：

ANTIESTROGENS; COACTIVATOR; ESTROGEN RECEPTOR; TRANSCRIPTIONAL ACTIVATION;

D O I：

10.1002/j.1460-2075.1995.tb00044.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A conserved region in the hormone-dependent activation domain AF2 of nuclear receptors plays an important role in transcriptional activation. We have characterized a novel nuclear protein, RIP140, that specifically interacts in vitro with this domain of the estrogen receptor. This interaction was increased by estrogen, but not by anti-estrogens and the in vitro binding capacity of mutant receptors correlates with their ability to stimulate transcription. RIP140 also interacts with estrogen receptor in intact cells and modulates its transcriptional activity in the presence of estrogen, but not the anti-estrogen 4-hydroxytamoxifen. In view of its widespread expression in mammalian cells, RIP140 may interact with other members of the superfamily of nuclear receptors and thereby act as a potential co-activator of hormone-regulated gene transcription.

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收藏

页码：3741 / 3751

页数：11

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