Frailty in Parkinson's disease and its clinical implications

被引：54

作者：

Ahmed, Naslya N. ^{[1
,3
]}

Sherman, Scott J. ^{[2
]}

VanWyck, David ^{[3
]}

机构：

[1] Univ Texas Houston, Sect Geriatr, Houston, TX 77030 USA

[2] Univ Arizona, Dept Neurol, Tucson, AZ 85721 USA

[3] Univ Arizona, Dept Internal Med, Sect Geriatr & Gerontol, Tucson, AZ 85721 USA

来源：

PARKINSONISM & RELATED DISORDERS | 2008年 / 14卷 / 04期

关键词：

frailty; Parkinson's disease; geriatrics;

D O I：

10.1016/j.parkreldis.2007.10.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The purpose of our study was to determine the prevalence of frailty in Parkinson's disease (PD) patients and the relationship between individual frailty criteria and the severity of PD. We measured the five components of frailty (Fried et al.) and the severity of PD (unified Parkinson's disease rating scale (UPDRS)) in 50 optimally treated PD patients. Frailty was more prevalent in PD patients. While UPDRS scores differed between frail and non-frail participants (44.8 +/- 15.8 vs. 31.4 +/- 12.7, P < 0.002), higher scores were not indicative of frailty. Weekly caloric expenditure best predicted frailty status (OR = 22.0 [4.5,107.8]). Frailty and PD bear distinct therapeutic and prognostic significance-, however, their clinical picture may overlap and screening PD patients for frailty may be warranted. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：334 / 337

页数：4

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