Adaptive immune responses in acute and chronic hepatitis C virus infection

被引：593

作者：

Bowen, DG

Walker, CM ^{[1
]}

机构：

[1] Columbus Childrens Res Inst, Ctr Vaccines & Immun, Columbus, OH 43205 USA

[2] Ohio State Univ, Coll Med & Publ Hlth, Columbus, OH 43210 USA

来源：

NATURE | 2005年 / 436卷 / 7053期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nature04079

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally. Recent studies have yielded important insights into immunity to HCV, in particular revealing the central role of T cells in viral control and clearance. Other key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.

引用

收藏

页码：946 / 952

页数：7

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