Plasmodium falciparum-infected erythrocytes demonstrate dual specificity for adhesion to hyaluronic acid and chondroitin sulfate a and have distinct adhesive properties

被引:58
作者
Beeson, JG [1 ]
Brown, GV [1 ]
机构
[1] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3050, Australia
基金
英国医学研究理事会;
关键词
D O I
10.1086/380975
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Hyaluronic acid (HA) and chondroitin sulfate A (CSA) have been identified as receptors for adhesion of Plasmodium falciparum-infected erythrocytes (IEs) and appear to be involved in mediating parasite accumulation in the placenta. We demonstrate here that some, but not all, parasite populations can adhere to both receptors, and we identify distinguishing features of adhesion. Adhesion to HA and CSA was greatest among pigmented trophozoite-infected erythrocytes and at physiologic pH and was associated with a lack of rosette formation and little adhesion to CD36 and intercellular adhesion molecule-1. Adhesion to HA was sensitive to trypsin cleavage of the IE surface, whereas trypsin-resistant and trypsin-sensitive CSA adhesion were both observed. Soluble HA, but not CSA, could cause aggregation or clumping of IEs. Different HA types varied in adhesion-inhibitory activity, which was altered by physical treatment, suggesting that structural features of HA influence IE interactions. These findings have important implications for understanding the pathogenesis of malaria, particularly in pregnancy.
引用
收藏
页码:169 / 179
页数:11
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共 70 条
[51]   Characterization of a neutrophil cell surface glycosaminoglycan that mediates binding of platelet factor 4 [J].
Petersen, F ;
Brandt, E ;
Lindahl, U ;
Spillmann, D .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (18) :12376-12382
[52]   The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1 [J].
Reeder, JC ;
Cowman, AF ;
Davern, KM ;
Beeson, JG ;
Thompson, JK ;
Rogerson, SJ ;
Brown, GV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :5198-5202
[53]   A SIMPLE METHOD FOR TYPING PLASMODIUM-FALCIPARUM MEROZOITE SURFACE ANTIGEN-1 AND ANTIGEN-2 (MSA-1 AND MSA-2) USING A DIMORPHIC-FORM SPECIFIC POLYMERASE CHAIN-REACTION [J].
REEDER, JC ;
MARSHALL, VM .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1994, 68 (02) :329-332
[54]   Chondroitin-4-sulphate (proteoglycan), a receptor for Plasmodium falciparum-infected erythrocyte adherence on brain microvascular endothelial cells [J].
Robert, C ;
Pouvelle, B ;
Meyer, P ;
Muanza, K ;
Fujioka, H ;
Aikawa, M ;
Scherf, A ;
Gysin, J .
RESEARCH IN IMMUNOLOGY, 1995, 146 (06) :383-393
[55]   RAPID SWITCHING TO MULTIPLE ANTIGENIC AND ADHESIVE PHENOTYPES IN MALARIA [J].
ROBERTS, DJ ;
CRAIG, AG ;
BERENDT, AR ;
PINCHES, R ;
NASH, G ;
MARSH, K ;
NEWBOLD, CI .
NATURE, 1992, 357 (6380) :689-692
[56]   Plasmodium falciparum-infected erythrocytes adhere to the proteoglycan thrombomodulin in static and flow-based systems [J].
Rogerson, SJ ;
Novakovic, S ;
Cooke, BM ;
Brown, GV .
EXPERIMENTAL PARASITOLOGY, 1997, 86 (01) :8-18
[57]   SULFATED GLYCOCONJUGATES AS DISRUPTERS OF PLASMODIUM-FALCIPARUM ERYTHROCYTE ROSETTES [J].
ROGERSON, SJ ;
REEDER, JC ;
ALYAMAN, F ;
BROWN, GV .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1994, 51 (02) :198-203
[58]   Plasmodium falciparum rosette formation is uncommon in isolates from pregnant women [J].
Rogerson, SJ ;
Beeson, JG ;
Mhango, CG ;
Dzinjalamala, FK ;
Molyneux, ME .
INFECTION AND IMMUNITY, 2000, 68 (01) :391-393
[59]   CHONDROITIN SULFATE A IS A CELL-SURFACE RECEPTOR FOR PLASMODIUM-FALCIPARUM-INFECTED ERYTHROCYTES [J].
ROGERSON, SJ ;
CHAIYAROJ, SC ;
NG, K ;
REEDER, JC ;
BROWN, GV .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (01) :15-20
[60]  
Rogerson SJ, 1999, ANN TROP MED PARASIT, V93, pS35, DOI 10.1080/00034989957727