The association of antihypertensive medication use with risk of cognitive decline and dementia: a meta-analysis of longitudinal studies

被引：63

作者：

Chang-Quan, H. ^{[1
,2
]}

Hui, W. ^{[2
]}

Chao-min, W. ^{[3
]}

Zheng-Rong, W. ^{[1
]}

Jun-Wen, G. ^{[1
]}

Yong-Hong, L. ^{[1
]}

Yan-You, L. ^{[1
]}

Qing-Xiu, L. ^{[2
]}

机构：

[1] Sichuan Univ, Key Lab Chronobiol, Minist Hlth, Basic & Forens Sch, Chengdu 610041, Peoples R China

[2] Third Hosp Mianyang, Dept Geriatr, Mianyang, Sichuan, Peoples R China

[3] Sichuan Univ, Dept Pediat, W China Hosp 2, Chengdu 610064, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2011年 / 65卷 / 12期

关键词：

INCIDENT ALZHEIMER-DISEASE; BLOOD-PRESSURE; DOUBLE-BLIND; SYSTOLIC HYPERTENSION; DIABETES-MELLITUS; CONTROLLED-TRIAL; PERINDOPRIL; IMPAIRMENT; INDAPAMIDE;

D O I：

10.1111/j.1742-1241.2011.02810.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The association of antihypertensive medication use with cognitive decline (including mild cognitive impairment) or dementia (including Alzheimers disease (AD), vascular dementia (VD) and any dementia) has still been an area of controversy. This study examined the association of antihypertensive medication use with cognitive decline or dementia using a quantitative meta-analysis of longitudinal studies. EMBASE and MEDLINE were searched for articles published up to Feb 2011. All studies that examined the relationship between antihypertensive medication use and the incidence of dementia or cognitive decline were included. Pooled relative risk (RR) was calculated using fixed and random-effects models. Fourteen studies met our inclusion criteria for this meta-analysis. All subjects were without dementia or cognitive impairment at baseline. There were subjects with (32,658) and without (36,905) antihypertensive medication use. The quantitative meta-analysis showed that there was no significant difference in incidence of AD (RR: 0.90, 95% confidence interval (CI): 0.791.03), cognitive decline (RR: 0.97; 95% CI: 0.921.03) and cognitive impairment (RR: 0.97; 95% CI: 0.921.03). The quantitative meta-analysis showed that the subjects with antihypertensive medication use were lower incidence of VD (RR: 0.67, 95% CI: 0.520.87) and any dementia (RR: 0.87; 95% CI: 0.770.96) than those without. The quantitative meta-analysis showed that antihypertensive medication use could decrease risk of the development of VD and any dementia, but could not decrease that of AD, cognitive decline and cognitive impairment.

引用

页码：1295 / 1305

页数：11

共 24 条

[1] Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies [J].

Anderson, Craig ;

Teo, Koon ;

Gao, Peggy ;

Arima, Hisatomi ;

Dans, Antonio ;

Unger, Thomas ;

Commerford, Patrick ;

Dyal, Leanne ;

Schumacher, Helmut ;

Pogue, Janice ;

Paolasso, Ernesto ;

Holwerda, Nicolaas ;

Chazova, Irina ;

Binbrek, Azan ;

Young, James ;

Yusuf, Salim .

LANCET NEUROLOGY, 2011, 10 (01) :43-53

[2] IMPACT OF THE TREATMENT OF ISOLATED SYSTOLIC HYPERTENSION ON BEHAVIORAL VARIABLES - RESULTS FROM THE SYSTOLIC HYPERTENSION IN THE ELDERLY PROGRAM [J].

APPLEGATE, WB ;

PRESSEL, S ;

WITTES, J ;

LUHR, J ;

SHEKELLE, RB ;

CAMEL, GH ;

GREENLICK, MR ;

HADLEY, E ;

MOYE, L ;

PERRY, HM ;

SCHRON, E ;

WEGENER, V .

ARCHIVES OF INTERNAL MEDICINE, 1994, 154 (19) :2154-2160

[3] Risk of dementia in diabetes mellitus: a systematic review [J].

Biessels, GJ ;

Staekenborg, S ;

Brunner, E ;

Brayne, C ;

Scheltens, P .

LANCET NEUROLOGY, 2006, 5 (01) :64-74

[4] Predictors of cognitive impairment and dementia in older people with diabetes [J].

Bruce, D. G. ;

Davis, W. A. ;

Casey, G. P. ;

Starkstein, S. E. ;

Clarnette, R. M. ;

Foster, J. K. ;

Almeida, O. P. ;

Davis, T. M. E. .

DIABETOLOGIA, 2008, 51 (02) :241-248

[5] The role of α2-agonists in neurosurgery [J].

Cormack, JR ;

Orme, RM ;

Costello, TG .

JOURNAL OF CLINICAL NEUROSCIENCE, 2005, 12 (04) :375-378

[6] Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial:: a double-blind, active and placebo-controlled study [J].

Dienert, Hans-Christoph ;

Saccot, Ralph L. ;

Yusuft, Salim ;

Cotton, Daniel ;

Ounpuu, Stephanie ;

Lawton, William A. ;

Palesch, Yuko ;

Martin, Renee H. ;

Albers, Gregory W. ;

Bath, Philip ;

Bornstein, Natan ;

Chan, Bernard P. L. ;

Chen, Sien-Tsong ;

Cunha, Luis ;

Dahlof, Bjorn ;

De Keyser, Jacques ;

Donnan, Geoffrey A. ;

Estol, Conrado ;

Gorelick, Philip ;

Gu, Vivian ;

Hermansson, Karin ;

Hilbrich, Lutz ;

Kaste, Markku ;

Lu, Chuanzhen ;

Machnig, Thomas ;

Pais, Prem ;

Roberts, Robin ;

Skvortsova, Veronika ;

Teal, Philip ;

Toni, Danilo ;

VanderMaelen, Cam ;

Voigt, Thor ;

Weber, Michael ;

Yoon, Byung-Woo .

LANCET NEUROLOGY, 2008, 7 (10) :875-884

[7] Longitudinal study of blood pressure and white matter hyperintensities -: The EVA MRI cohort [J].

Dufouil, C ;

de Kersaint-Gilly, A ;

Besançon, V ;

Levy, C ;

Auffray, E ;

Brunnereau, L ;

Alpérovitch, A ;

Tzourio, C .

NEUROLOGY, 2001, 56 (07) :921-926

[8] Emerging therapies for vascular dementia and vascular cognitive impairment [J].

Erkinjuntti, T ;

Román, G ;

Gauthier, S ;

Feldman, H ;

Rockwood, K .

STROKE, 2004, 35 (04) :1010-1017

[9] Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial [J].

Forette, F ;

Seux, ML ;

Staessen, JA ;

Thijs, L ;

Birkenhäger, WH ;

Babarskiene, MR ;

Babeanu, S ;

Bossini, A ;

Gil-Extremera, B ;

Girerd, X ;

Laks, T ;

Lilov, E ;

Moisseyev, V ;

Tuomilehto, J ;

Vanhanen, H ;

Webster, J ;

Yodfat, Y ;

Fagard, R .

LANCET, 1998, 352 (9137) :1347-1351

[10]

ITO S, 1992, HYPERTENSION, V19, P164

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