Telomeres and essential hypertension

被引：17

作者：

Aviv, A

Aviv, H

机构：

[1] Univ Med & Dent New Jersey, Hypertens Res Ctr, New Jersey Med Sch, Newark, NJ 07103 USA

[2] Univ Med & Dent New Jersey, Ctr Human & Mol Genet, New Jersey Med Sch, Newark, NJ 07103 USA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1999年 / 12卷 / 04期

关键词：

genetics; genetic linkage; phenotype; complex trait; aneuploidy; telomere attrition; essential hypertension;

D O I：

10.1016/S0895-7061(98)00202-7

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The dynamics of telomere attrition in human beings might shape the course of age-dependent, complex genetic traits. One of these traits is essential hypertension. Age-dependent telomere attrition could lead to critically shortened telomeres and aneuploidy (ie, the loss or gain of chromosomes) with a resultant mosaicism that will be variably expressed in different cells and tissues. The chromosomal instability and loss of heterozygosity resulting from this process would promote an age-dependent expression of variant genes that harbor susceptibility for essential hypertension or genes that accelerate the process of aging. (C) 1999 American Journal of Hypertension, Ltd.

引用

页码：427 / 432

页数：6

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