Ligand- and base-free copper(II)-catalyzed C-N bond formation: Cross-coupling reactions of organoboron compounds with aliphatic amines and anilines

被引:215
作者
Quach, TD [1 ]
Batey, RA [1 ]
机构
[1] Univ Toronto, Dept Chem, Daven Res Labs, Toronto, ON M5S 3H6, Canada
关键词
D O I
10.1021/ol035681s
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A ligandless and base-free Cu-catalyzed protocol for the cross-coupling of arylboronic acids and potassium aryltrifluoroborate salts with primary and secondary aliphatic amines and anilines is described. The process utilizes catalytic copper(II) acetate monohydrate and 4 Angstrom molecular sieves in dichloromethane at slightly elevated temperatures under an atmosphere of oxygen. A broad range of functional groups are tolerated on both of the cross-coupling partners.
引用
收藏
页码:4397 / 4400
页数:4
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