Enabling personalized cancer medicine through analysis of gene-expression patterns

被引：396

作者：

van 't Veer, Laura J. ^{[1
,2
,3
]}

Bernards, Rene ^{[1
,3
,4
,5
]}

机构：

[1] Agendia BV, NL-1066 EC Amsterdam, Netherlands

[2] Netherlands Canc Inst, Div Pathol, NL-1066 CX Amsterdam, Netherlands

[3] Netherlands Canc Inst, Canc Genom Ctr, NL-1066 CX Amsterdam, Netherlands

[4] Netherlands Canc Inst, Ctr Biomed Genet, NL-1066 CX Amsterdam, Netherlands

[5] Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

来源：

NATURE | 2008年 / 452卷 / 7187期

关键词：

D O I：

10.1038/nature06915

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more- specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who require therapy and those who are most likely to benefit from certain therapies. In particular, tests that predict the clinical outcome for patients on the basis of the genes expressed by their tumours are likely to increasingly affect patient management, heralding a new era of personalized medicine.

引用

页码：564 / 570

页数：7

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