Neural circuit changes mediating lasting brain and behavioral response to predator stress

被引：102

作者：

Adamec, RE ^{[1
]}

Blundell, J ^{[1
]}

Burton, P ^{[1
]}

机构：

[1] Mem Univ Newfoundland, Dept Psychol, St John, NF A1B 3X9, Canada

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2005年 / 29卷 / 08期

关键词：

amygdala; anxiety; LTP; neuroplasticity; PAG; path analysis; predator stress; PTSD;

D O I：

10.1016/j.neubiorev.2005.05.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This paper reviews recent work which points to critical neural circuitry involved in lasting changes in anxiety like behavior following unprotected exposure of rats to cats (predator stress). Predator stress may increase anxiety like behavior in a variety of behavioral tests including: elevated plus maze, light dark box, acoustic startle, and social interaction. Studies of neural transmission in two limbic pathways, combined with path and covariance analysis relating physiology to behavior, suggest long term potentiation like changes in one or both of these pathways in the right hemisphere accounts for stress induced changes in all behaviors changed by predator stress except light dark box and social interaction. Findings will be discussed within the context of what is known about neural substrates activated by predator odor. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1225 / 1241

页数：17

共 98 条

[21] NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala [J].

Bauer, EP ;

Schafe, GE ;

LeDoux, JE .

JOURNAL OF NEUROSCIENCE, 2002, 22 (12) :5239-5249

[22] Fear conditioning and LTP in the lateral amygdala ave sensitive to the same stimulus contingencies [J].

Bauer, EP ;

LeDoux, JE ;

Nader, K .

NATURE NEUROSCIENCE, 2001, 4 (07) :687-688

[23]

Bentler P. M., 2006, EQS 6 structural equations program manual

[24] mCPP-induced anxiety in the light-dark box in rats -: a new method for screening anxiolytic activity [J].

Bilkei-Gorzó, A ;

Gyertyán, I ;

Lévay, G .

PSYCHOPHARMACOLOGY, 1998, 136 (03) :291-298

[25] Synaptic plasticity in the lateral amygdala: A cellular hypothesis of fear conditioning [J].

Blair, HT ;

Schafe, GE ;

Bauer, EP ;

Rodrigues, SM ;

LeDoux, JE .

LEARNING & MEMORY, 2001, 8 (05) :229-242

[26] Behavioral and endocrine change following chronic predatory stress [J].

Blanchard, RJ ;

Nikulina, JN ;

Sakai, RR ;

McKittrick, C ;

McEwen, B ;

Blanchard, DC .

PHYSIOLOGY & BEHAVIOR, 1998, 63 (04) :561-569

[27] ANTIPREDATOR DEFENSIVE BEHAVIORS IN A VISIBLE BURROW SYSTEM [J].

BLANCHARD, RJ ;

BLANCHARD, DC .

JOURNAL OF COMPARATIVE PSYCHOLOGY, 1989, 103 (01) :70-82

[28] Neurochemical mechanisms of the defensive behavior in the dorsal midbrain [J].

Brandao, ML ;

Anseloni, VZ ;

Pandóssio, JE ;

De Araujo, JE ;

Castilho, VM .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1999, 23 (06) :863-875

[29]

Byrne B. M., 1994, STRUCTURAL EQUATION

[30]

Cameron JS, 1999, J AM SOC NEPHROL, V10, P413

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