Dendritic cells giveth and taketh away

被引：20

作者：

Abbas, AK ^{[1
]}

Sharpe, AH

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2005年 / 6卷 / 03期

关键词：

D O I：

10.1038/ni0305-227

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Resting dendritic cells can induce T cell tolerance. This process requires engagement of the costimulatory molecules PD-1 and CTLA-4 on T cells.

引用

页码：227 / 228

页数：2

共 12 条

[1]

Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: Attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses [J].

Bennett, F ;

Luxenberg, D ;

Ling, V ;

Wang, IM ;

Marquette, K ;

Lowe, D ;

Khan, N ;

Veldman, G ;

Jacobs, KA ;

Valge-Archer, VE ;

Collins, M ;

Carreno, BM .

JOURNAL OF IMMUNOLOGY, 2003, 170 (02) :711-718

[2]

CTLA-4 regulates induction of anergy in vivo [J].

Greenwald, RJ ;

Boussiotis, VA ;

Lorsbach, RB ;

Abbas, AK ;

Sharpe, AH .

IMMUNITY, 2001, 14 (02) :145-155

[3]

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo [J].

Hawiger, D ;

Inaba, K ;

Dorsett, Y ;

Guo, M ;

Mahnke, K ;

Rivera, M ;

Ravetch, JV ;

Steinman, RM ;

Nussenzweig, MC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (06) :769-779

[4]

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells [J].

Latchman, YE ;

Liang, SC ;

Wu, Y ;

Chernova, T ;

Sobel, RA ;

Klemm, M ;

Kuchroo, VK ;

Freeman, GJ ;

Sharpe, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) :10691-10696

[5]

The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens [J].

Lohr, J ;

Knoechel, B ;

Jiang, SW ;

Sharpe, AH ;

Abbas, AK .

NATURE IMMUNOLOGY, 2003, 4 (07) :664-669

[6]

Dendritic cells in immunity and tolerance - Do they display opposite functions? [J].

Moser, M .

IMMUNITY, 2003, 19 (01) :5-8

[7]

Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement [J].

Perez, VL ;

VanParijs, L ;

Biuckians, A ;

Zheng, XX ;

Strom, TB ;

Abbas, AK .

IMMUNITY, 1997, 6 (04) :411-417

[8]

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4 [J].

Probst, HC ;

McCoy, K ;

Okazaki, T ;

Honjo, T ;

van den Broek, M .

NATURE IMMUNOLOGY, 2005, 6 (03) :280-286

[9]

Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance [J].

Probst, HC ;

Lagnel, J ;

Kollias, G ;

van den Broek, M .

IMMUNITY, 2003, 18 (05) :713-720

[10]

Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation [J].

Salomon, B ;

Bluestone, JA .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :225-252

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