C4b-binding protein (C4BP) activates B cells through the CD40 receptor

被引：107

作者：

Brodeur, SR

Angelini, F

Bacharier, LB

Blom, AM

Mizoguchi, E

Fujiwara, H

Plebani, A

Notarangelo, LD

Dahlback, B

Tsitsikov, E

Geha, RS ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Div Immunol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[3] Lund Univ, Dept Clin Chem, Malmo, Sweden

[4] Massachusetts Gen Hosp, Dept Pathol, Boston, MA USA

[5] Univ Brescia, Dept Pediat, Brescia, Italy

[6] Univ Brescia, Inst Mol Med Angelo Nocivelli, Brescia, Italy

[7] Univ Roma Tor Vergata, Dept Pediat, Rome, Italy

[8] Washington Univ, Dept Pediat, St Louis, MO 63130 USA

[9] Osaka Univ, Dept Med, Osaka, Japan

来源：

IMMUNITY | 2003年 / 18卷 / 06期

关键词：

D O I：

10.1016/S1074-7613(03)00149-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.

引用

页码：837 / 848

页数：12

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