Exercise your amyloid

被引:10
作者
Karsten, SL [1 ]
Geschwind, DH [1 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA
关键词
D O I
10.1016/j.cell.2005.02.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The interplay of genetics and the environment in the etiology of Alzheimer's disease (AD) is not well understood. Now, Lazarov and coworkers (Lazarov et al., 2005 [this issue of Cell]) show that a simple paradigm of environmental enrichment alleviates amyloid burden and alters disease-associated gene expression changes in a double transgenic mouse model of AD.
引用
收藏
页码:572 / 574
页数:3
相关论文
共 10 条
[1]   Memory and executive function in aging and AD: Multiple factors that cause decline and reserve factors that compensate [J].
Buckner, RL .
NEURON, 2004, 44 (01) :195-208
[2]   An active and socially integrated lifestyle in late life might protect against dementia [J].
Fratiglioni, L ;
Paillard-Borg, S ;
Winblad, B .
LANCET NEUROLOGY, 2004, 3 (06) :343-353
[3]   DNA microarrays: translation of the genome from laboratory to clinic [J].
Geschwind, DH .
LANCET NEUROLOGY, 2003, 2 (05) :275-282
[4]   Identification of the major Aβ1-42-degrading catabolic pathway in brain parenchyma:: Suppression leads to biochemical and pathological deposition [J].
Iwata, N ;
Tsubuki, S ;
Takaki, Y ;
Watanabe, K ;
Sekiguchi, M ;
Hosoki, E ;
Kawashima-Morishima, M ;
Lee, HJ ;
Hama, E ;
Sekine-Aizawa, Y ;
Saido, TC .
NATURE MEDICINE, 2000, 6 (02) :143-150
[5]   Environmental enrichment reduces Aβ levels and amyloid deposition in transgenic mice [J].
Lazarov, O ;
Robinson, J ;
Tang, YP ;
Hairston, IS ;
Korade-Mirnics, Z ;
Lee, VMY ;
Hersh, LB ;
Sapolsky, RM ;
Mirnics, K ;
Sisodia, SS .
CELL, 2005, 120 (05) :701-713
[6]   Age-related amyloid β deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid β precursor protein Swedish mutant is not associated with global neuronal loss [J].
Takeuchi, A ;
Irizarry, MC ;
Duff, K ;
Saido, TC ;
Ashe, KH ;
Hasegawa, M ;
Mann, DMA ;
Hyman, BT ;
Iwatsubo, T .
AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (01) :331-339
[7]   Clearance of Alzheimer's Aβ peptide:: The many roads to perdition [J].
Tanzi, RE ;
Moir, RD ;
Wagner, SL .
NEURON, 2004, 43 (05) :605-608
[8]   PHYSICAL BASIS OF COGNITIVE ALTERATIONS IN ALZHEIMERS-DISEASE - SYNAPSE LOSS IS THE MAJOR CORRELATE OF COGNITIVE IMPAIRMENT [J].
TERRY, RD ;
MASLIAH, E ;
SALMON, DP ;
BUTTERS, N ;
DETERESA, R ;
HILL, R ;
HANSEN, LA ;
KATZMAN, R .
ANNALS OF NEUROLOGY, 1991, 30 (04) :572-580
[9]   Delaying the onset of Huntington's in mice [J].
van Dellen, A ;
Blakemore, C ;
Deacon, R ;
York, D ;
Hannan, AJ .
NATURE, 2000, 404 (6779) :721-722
[10]   Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus [J].
van Praag, H ;
Kempermann, G ;
Gage, FH .
NATURE NEUROSCIENCE, 1999, 2 (03) :266-270