Morphogen gradient from a noisy source

被引：36

作者：

England, JL

Cardy, J

机构：

[1] Univ Oxford, Rudolf Peierls Ctr Theoret Phys, Oxford OX1 3NP, England

[2] Univ Oxford All Souls Coll, Oxford OX1 4AL, England

来源：

PHYSICAL REVIEW LETTERS | 2005年 / 94卷 / 07期

关键词：

D O I：

10.1103/PhysRevLett.94.078101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed.

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页数：4

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