Serum Soluble Mesothelin Concentrations in Malignant Pleural Mesothelioma: Relationship to Tumor Volume, Clinical Stage and Changes in Tumor Burden

被引：89

作者：

Creaney, Jenette ^{[1
,2
]}

Francis, Roslyn J. ^{[1
,3
]}

Dick, Ian M. ^{[1
]}

Musk, Arthur W. ^{[1
,6
]}

Robinson, Bruce W. S. ^{[1
,2
,4
]}

Byrne, Michael J. ^{[1
,5
]}

Nowak, Anna K. ^{[1
,5
]}

机构：

[1] Univ Western Australia, Sch Med & Pharmacol, Natl Res Ctr Asbestos Related Dis, Nedlands, WA 6009, Australia

[2] Australian Mesothelioma Tissue Bank, Nedlands, WA, Australia

[3] Univ Western Australia, Sir Charles Gairdner Hosp, Dept Nucl Med, Nedlands, WA 6009, Australia

[4] Univ Western Australia, Sir Charles Gairdner Hosp, Dept Resp Med, Nedlands, WA 6009, Australia

[5] Univ Western Australia, Sir Charles Gairdner Hosp, Dept Med Oncol, Nedlands, WA 6009, Australia

[6] Univ Western Australia, Sch Populat Hlth, Nedlands, WA 6009, Australia

来源：

CLINICAL CANCER RESEARCH | 2011年 / 17卷 / 05期

基金：

英国医学研究理事会;

关键词：

POSITRON-EMISSION-TOMOGRAPHY; RESPONSE EVALUATION; TRIMODALITY THERAPY; COLORECTAL-CANCER; RECIST CRITERIA; OSTEOPONTIN; INADEQUACY; GUIDELINES; DIAGNOSIS; SURVIVAL;

D O I：

10.1158/1078-0432.CCR-10-1929

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To examine the clinical utility of soluble mesothelin in patients with malignant pleural mesothelioma. Experimental Design: A total of 97 patients (female: 11; male: 86) were prospectively enrolled, longitudinal serum samples collected, and mesothelin concentrations determined. Baseline mesothelin levels were analyzed relative to tumor stage, presence of metastatic disease, the positron emission tomography (PET) parameters maximum standardized uptake value, tumor volume, total glycolytic volume, and survival. Changes in mesothelin level were correlated to objective response to chemotherapy, as assessed radiologically and by PET imaging, and with patient survival. Results: Baseline mesothelin levels greater than 5 nmol/L were a significant negative prognostic indicator (HR = 2.25; 95% CI, 1.20-4.21) and correlated with tumor stage and volume. In 55 patients who received chemotherapy, change in mesothelin correlated with radiological response (chi(2) = 11.32; P = 0.023) and change in metabolically active tumor volume (r = 0.58; P < 0.01). Median survival for patients with a reduction in mesothelin following chemotherapy (19 months) was significantly longer than for patients with increased mesothelin (5 months; P < 0.001). Conclusion: These findings show the potential value of changes in mesothelin levels for prognostication and monitoring of treatment response in mesothelioma. Clin Cancer Res; 17(5); 1181-9. (C)2010 AACR.

引用

页码：1181 / 1189

页数：9

共 33 条

[1] Variability in mesothelioma tumor response classification [J].