Iridium-complex-functionalized Fe3O4/SiO2 core/shell nanoparticles:: A facile three-in-one system in magnetic resonance imaging, luminescence imaging, and photodynamic therapy

被引：206

作者：

Lai, Chih-Wei ^{[1
]}

Wang, Yu-Hsiu ^{[1
]}

Lai, Cheng-Hsuan ^{[1
]}

Yang, Meng-Ju ^{[1
]}

Chen, Chun-Yen ^{[1
]}

Chou, Pi-Tai ^{[1
]}

Chan, Chi-Shun ^{[2
]}

Chi, Yun ^{[2
]}

Chen, Yu-Chun ^{[3
,4
]}

Hsiao, Jong-Kai ^{[3
,4
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Med Imaging, Taipei 105, Taiwan

[4] Coll Med, Taipei 105, Taiwan

来源：

SMALL | 2008年 / 4卷 / 02期

关键词：

biomaterials; imaging; iridium; photodynamic therapy; silicates; SUPERPARAMAGNETIC IRON-OXIDE; SEMICONDUCTOR QUANTUM DOTS; MRI CONTRAST AGENTS; SILICA NANOPARTICLES; FLUORESCENT; AGGREGATION; DESIGN; DRUG;

D O I：

10.1002/smll.200700283

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly uniform Fe3O4/SiO2 core/shell nanoparticles functionalized by phosphorescent iridium complexes (Ir) have been strategically designed and synthesized. The Fe3O4/SiO2(Ir) nanocomposite demonstrates its versatility in various applications: the magnetic core provides the capability for magnetic resonance imaging and the great enhancement of the spinorbit coupling in the iridium complex makes it well suited for phosphorescent labeling and simultaneous singlet oxygen generation to induce apoptosis.

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页码：218 / 224

页数：7

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