Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo

被引：60

作者：

Mouton, Johan W.

Punt, Nieko

Vinks, Alexander A.

机构：

[1] Canisius Wilhelmina Ziekenhuis Nijmegen, Dept Med Microbiol & Infect Dis, NL-6532 SZ Nijmegen, Netherlands

[2] Cincinnati Childrens Hosp, Med Ctr, Pediat Pharmacol Res Unit, Cincinnati, OH USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 09期

关键词：

D O I：

10.1128/AAC.01586-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Growth-kill dynamics were characterized in vitro, and the parameter estimates were used to simulate bacterial growth and kill in vivo using both mouse and human pharmacokinetics. The parameter estimates obtained in vitro predicted a time above the MIC of between 35 and 38% for a static effect in mice after 24 h of treatment.

引用

页码：3449 / 3451

页数：3

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