IL-10-producing T cells and their dual functions

被引：103

作者：

Bedke, Tanja ^{[1
]}

Muscate, Franziska ^{[2
]}

Soukou, Shiwa ^{[1
]}

Gagliani, Nicola ^{[1
,2
,3
]}

Huber, Samuel ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Med 1, D-20246 Hamburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Dept Gen Visceral & Thorac Surg, D-20246 Hamburg, Germany

[3] Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, S-17176 Stockholm, Sweden

来源：

SEMINARS IN IMMUNOLOGY | 2019年 / 44卷

基金：

欧洲研究理事会;

关键词：

Interleukin-10; T-cells; Immune regulation; Inflammation; RECOMBINANT HUMAN INTERLEUKIN-10; TRANSCRIPTION FACTOR; DENDRITIC CELLS; GRANZYME-B; IFN-GAMMA; MEDIATED SUPPRESSION; INFECTION PROMOTES; REGULATORY CELLS; IMMUNE TOLERANCE; IL-10; PRODUCTION;

D O I：

10.1016/j.smim.2019.101335

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Interleukin (IL)-10 is considered a prototypical anti-inflammatory cytokine, which significantly contributes to the maintenance and reestablishment of immune homeostasis. However, this classical view fails to fully describe the pleiotropic roles of IL-10. Indeed, IL-10 can also promote immune responses, e.g. by supporting B-cell and CD8(+) T-cell activation. The reasons for these seemingly opposing functions are unclear to a large extent. Recent and previous studies suggest that the cellular source and the microenvironment impact the function of IL-10. However, studies addressing the mechanisms which determine whether IL-10 promotes inflammation or controls it have just begun. This review first summarizes the recent findings on the heterogeneity of IL-10 producing T cells and their impact on the target cells. Finally, we will propose two possible explanations for the dual functions of IL-10.

引用

页数：9

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